Cefmetazol

Bezeichnung:Cefmetazol

CAS-Nr56796-20-4

Englisch Name:Cefmetazole

CBNumberCB9231320

SummenformelC15H17N7O5S3

Molgewicht471.53

MOL-Datei56796-20-4.mol

Synonyma

Cefmetazol

Cefmetazol physikalisch-chemischer Eigenschaften

Schmelzpunkt	163-165?C
Dichte	1.4380 (rough estimate)
Brechungsindex	1.7400 (estimate)
storage temp.	2-8°C
Löslichkeit	Methanol (Slightly, Heated)
Aggregatzustand	Solid
pka	2.65±0.50(Predicted)
Farbe	White
Wasserlöslichkeit	Soluble in water
CAS Datenbank	56796-20-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	36/37/38-42/43
S-Sätze:	26-36
WGK Germany	2
RTECS-Nr.	XI0372200
HS Code	2941906000

Gefahreninformationscode (GHS)

Cefmetazole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Cefmetazole is a cephamycin with a nonaromatic side chain at C-7. In addition to a fairly characteristic second-generation cephalosporin antimicrobial spectrum, it possess fairly significant anti-antiaerobic activity. The ejection of its C-3 side chain leads to alcohol intolerance of the disulfuram type and prolonged clotting times.
Allgemeine Beschreibung
Cefmetazole was synthesized by Sankyo Co. in 1976starting with a biosynthetic cephamycin. It shows excellent activity against Serratia and Proteus, against which cefazolin is not active, and it has stronger activity than cefoxitin, another derivative of cephamycin. Cefmetazole is active against anaerobes and resistant to β-lactamase, but it is not active against Pseudomonas aeruginosa.
Chemische Eigenschaften
White Solid
Verwenden
Semi-synthetic antibiotic derived from Cephamycin. Antibacterial.
Verwenden
A broad spectrum second generation cephalosporin antibiotic
Definition
ChEBI: A cephalosporin antibiotic containg an N1-methyltetrazol-5-ylthiomethyl side-chain at C-3 of the parent cephem bicyclic structure.
Antimicrobial activity
It is active against Pr. mirabilis, Pr. vulgaris, Morganella morganii, Yersinia spp.and most anaerobes. S. marcescens is moderately susceptible, but Ps. aeruginosa and E. faecalis are resistant. It is active against Mycobacterium fortuitum and some strains of M. chelonei. It is resistant to a wide range of β-lactamases.
The serum concentration at the end of a 1 g intravenous infusion is around 77 mg/L. Plasma protein binding is 68%. It is principally excreted in the urine with a plasma half-life of c. 1.3 h; 70% is recovered over the first 6 h. In patients whose creatinine clearance is less than 10 mL/min, plasma levels are elevated and the plasma half-life is increased to around 15 h.
Side effects associated with the methylthiotetrazole group at position C-3 have been reported. Uses are similar to those of cefoxitin, but it is not widely available.

Cefmetazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

56796-20-4, Cefmetazole Verwandte Suche:

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