Temazepam

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P330：Mund ausspülen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

TEMAZEPAM Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R11:Leichtentzündlich.

• S-Sätze Betriebsanweisung:

  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

• Chemische Eigenschaften

  Crystalline Solid

• Originator

  Levanxol,Carlo Erba,Italy,1970

• Verwenden

  Pharmacologically active labelled metabolite of Diazepam. Controlled substance (depressant). Sedative, hypnotic

• Verwenden

  Pharmacologically active metabolite of Diazepam. Controlled substance (depressant). Sedative, hypnotic

• Verwenden

  Temazepam, is pharmacologically active metabolite of Diazepam (D416855). It is Sedative, and hypnotic. Controlled substance (depressant).

• Definition

  ChEBI: Temazepam is a benzodiazepine.

• Manufacturing Process

  According to British Patent 1,022,645 3.4 g of 3-acetoxy-7-chloro-1-methyl-5- phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one suspended in 80 ml alcohol was treated with 6 ml of 4 N NaOH. After complete solution had taken place, a solid precipitated; this solid was redissolved by the addition of 80 ml of water. The solution was acidified with acetic acid to give white crystals which were recrystallized from alcohol to yield 7-chloro-3-hydroxy-5-phenyl-1- methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, MP 119° to 121°C.

• Trademarks

  Restoril (Tyco); Temaz (Quantum Pharmics).

• Therapeutic Function

  Tranquilizer

• Weltgesundheitsorganisation (WHO)

  Temazepam is a widely used benzodiazepine derivative. As with other drugs in this class, cases of misuse and drug dependence are known.

• Allgemeine Beschreibung

  Temazepam, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl -2H-1,4-benzodiazepine-2-one(Restoril), also occurs as a minor metabolite of diazepam.It can be visualized as N-methyl oxazepam, and indeed, asmall amount of N-demethylation occurs slowly. However,metabolism proceeds mainly through glucuronidationof the 3-hydroxyl group, thus, it is intermediate acting andmarketed as a hypnotic said to have little or no residualeffect.

• Clinical Use

  Benzodiazepine:
  Insomnia (short-term use)
  Pre-med anxiolytic prior to minor procedures

• Arzneimittelwechselwirkung

  Potentially hazardous interactions with other drugs
  Antibacterials: metabolism possibly increased by rifampicin.
  Antipsychotics: increased sedative effects; risk of serious adverse effects in combination with clozapine.
  Antivirals: concentration possibly increased by ritonavir.
  Disulfiram: metabolism of temazepam inhibited (increased toxicity).
  Sodium oxybate: enhanced effects of sodium oxybate - avoid.

• Stoffwechsel

  Temazepam is metabolised mainly in the liver. It is excreted mainly in the urine in the form of its inactive glucuronide conjugate together with small amounts of the demethylated derivative, oxazepam, also in conjugated form.

TEMAZEPAM Upstream-Materialien And Downstream Produkte

846-50-4, TEMAZEPAM Verwandte Suche: