Halcinonid

Bezeichnung:Halcinonid

CAS-Nr3093-35-4

Englisch Name:Halcinonide

CBNumberCB9106428

SummenformelC24H32ClFO5

Molgewicht454.96

MOL-Datei3093-35-4.mol

Synonyma

Halcinonid

Halcinonid physikalisch-chemischer Eigenschaften

Schmelzpunkt	264-265° (dec)
alpha	D25 +155° (CHCl3)
Siedepunkt	564.3±50.0 °C(Predicted)
Dichte	1.1567 (estimate)
storage temp.	-20°C Freezer
Löslichkeit	Chloroform (Slightly), Ethyl Acetate (Slightly)
Aggregatzustand	Solid
pka	13.19±0.70(Predicted)
Farbe	White to Off-White
InChIKey	MUQNGPZZQDCDFT-JNQJZLCISA-N
SMILES	O1[C@]2([H])C[C@]3([H])[C@@](C)([C@]2(C(CCl)=O)OC1(C)C)C[C@H](O)[C@]1(F)[C@]2(C)C(=CC(=O)CC2)CC[C@@]31[H]
CAS Datenbank	3093-35-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	63
S-Sätze:	36
WGK Germany	3
RTECS-Nr.	TU5010200
HS Code	2937220000
Toxizität	LD50 i.p. in mice: 150 mg/kg (Millonig, Yiakas)

Gefahreninformationscode (GHS)

Halcinonide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Originator
Halog,Squibb,US,1974
Verwenden
2H-Naphth[2'',1'':4,5]indeno[1,2-d][1,3]dioxole Pregn-4-ene-3,20-dione Deriv. is a by-product from the synthesis of 4-Fluorotriamcinolone Acetonide (F598640) an analog of Fluocinolone Acetonide (F455800); a glucocorticoid and anti-inflammatory agent.
Verwenden
Anti-inflammatory (topical).
Definition
ChEBI: Halcinonide is an organic molecular entity. It has a role as a SMO receptor agonist.
Indications
Halcinonide (Halog, Halog-E) is a synthetic fluorinated corticosteroid.
Manufacturing Process
(A) 16α-Hydroxy-9α-fluorohydrocortisone acetonide 27-mesylate: To a solution of 1.5 g of 16α-hydroxy-9α-fluorohydroortisone acetonide in 15 ml of dry pyridine is added at 0°C. 1.5 ml of methane-sulfonyl chloride. After standing in the refrigerator for 2,5 hours, excess methanesulfonyl chloride is destroyed by the addition of a small amount of ice, after which ice-water is added slowly to precipitate the reaction product. After ? hour in the refrigerator the material is filtered off, washed thoroughly with water and dried in vacuo. The resulting crude material after recrystallization from acetone-hexane gives the pure 21-mesylate of the following properties: melting point about 225°C to 227°C (decomposition); [α]D23+112° (c, 0.5 in chloroform).
(B) 21-Chloro-9α-fluoro-δ4-pregnene-11β,16α,17α-triol-3,20-dione16,17- acetonide : A solution of 200 mg of the acetonide 21-mesylate from part (A) and 900 mg of lithium chloride in 25 ml of dimethylformamide is kept at 100°C for 24 hours. The mixture is poured on ice, extracted with chloroform and the chloroform extract washed with water and dried over sodium sulfate. Evaporation of the solvent in vacuo furnishes the crystalline chloride, which after recrystallization from acetone-ethanol has a melting point about 276°C to 277°C.
Trademarks
Halog (Bristol-Myers Squibb); Halog (Westwood-Squibb).
Therapeutic Function
Topical corticosteroid
Allgemeine Beschreibung
Halcinonide, 21-chloro-9-fluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione, was the first chloroGC marketed. Likemany other potent GCs, it is used only topically.

Halcinonide Upstream-Materialien And Downstream Produkte

Halcinonid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3093-35-4, Halcinonide Verwandte Suche:

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