BIS(2,2,2-TRIFLUOROETHYL) ETHER

Bezeichnung:BIS(2,2,2-TRIFLUOROETHYL) ETHER

CAS-Nr333-36-8

Englisch Name:BIS(2,2,2-TRIFLUOROETHYL) ETHER

CBNumberCB8723208

SummenformelC4H4F6O

Molgewicht182.06

MOL-Datei333-36-8.mol

BIS(2,2,2-TRIFLUOROETHYL) ETHER physikalisch-chemischer Eigenschaften

Schmelzpunkt	25°C
Siedepunkt	62-63 °C (lit.)
Dichte	1.404 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.300(lit.)
Flammpunkt	35 °F
storage temp.	Flammables area
Löslichkeit	DMSO : ≥ 125 mg/mL (686.59 mM)
Aggregatzustand	clear liquid
Farbe	Colorless to Almost colorless
Wichte	1.41
Merck	14,4201
BRN	1811927
CAS Datenbank	333-36-8(CAS DataBase Reference)
EPA chemische Informationen	HFE-356mff2 (333-36-8)

Sicherheit

Kennzeichnung gefährlicher	F,Xi,T
R-Sätze:	11-36/37/38
S-Sätze:	16-26-36
RIDADR	UN 3271 3/PG 2
WGK Germany	3
RTECS-Nr.	KN3675000
Hazard Note	Flammable/Toxic/Convulsant
HazardClass	3.1
PackingGroup	II
HS Code	29091990

Gefahreninformationscode (GHS)

BIS(2,2,2-TRIFLUOROETHYL) ETHER Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
clear colorless liquid
Originator
Indoklon ,Ohio Medical, US ,1964
Verwenden
Bis(2,2,2-trifluoroethyl) Ether is Prophylactic and/or therapeutic agent for Alzheimer''s disease.
Verwenden
Bis(2,2,2-trifluoroethyl) ether was used to diminish self-discharge of Li-S cells having both low- and high-sulfur-loading sulfur cathodes.
Verwenden
5HT agonist
Definition
ChEBI: Flurotyl is an ether.
Manufacturing Process
23 parts of sodium metal were placed in 300 parts of dry dioxane in a reactor equipped with an agitator and reflux condenser. The dioxane was heated to reflux while stirring.150 parts of 2,2,2-trifluoroethanol were added very slowly in the period of about 1 hour, or until the sodium was all reacted, to form sodium 2,2,2-trifluoroethylate. 250 parts of 2,2,2-trifluoroethyl ptoluenesulfonate prepared by reacting 2,2,2-trifluoroethanol with p Flurothyl toluenesulfonyl chloride were placed in another reactor and heated to about 160° to 185°C. The solution of sodium 2,2,2-trifluoroethylate in dioxane was added very slowly over a period of about 1? hours. Bis(2,2,2-trifluoroethyl) ether formed continuously and distilled from the reactor with the dioxane into a cooled receiving vessel. The condensed effluent from the reactor was fractionally distilled, yielding 46.5 parts of products boiling at 55° to 73°C.
The crude product was washed successively with concentrated HCl, 62% H2SO4,concentrated H2SO4 and 5% NaOH solution. It was dehydrated over a drying agent and then refractionated in a still. 20 parts of bis(2,2,2trifluoroethyl) ether were recovered (BP 62.5° to 63.5°C).
Trademarks
Indoklon (Ohmeda).
Therapeutic Function
Central stimulant, Convulsant

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