NOURSEOTHRICIN SULFATE Struktur

NOURSEOTHRICIN SULFATE

Bezeichnung:NOURSEOTHRICIN SULFATE

CAS-Nr96736-11-7

Englisch Name:NOURSEOTHRICIN SULFATE

CBNumberCB8667052

SummenformelC44H82N18O21S

Molgewicht1231.29488

MOL-Datei96736-11-7.mol

NOURSEOTHRICIN SULFATE physikalisch-chemischer Eigenschaften

storage temp.	2-8°C
Löslichkeit	H2O: soluble200mg/mL
Aggregatzustand	solid
Farbe	white to light brown

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	RD4240000
F	10
HS Code	2941900000

Gefahreninformationscode (GHS)

NOURSEOTHRICIN SULFATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Streptothricin sulfate is a broad spectrum antibacterial compound with antiviral activity.
Biologische Aktivität
nourseothricin is a broad-spectrum antibiotic.nourseothricin is a broad-spectrum antibiotic derived from streptomyces noursei.
in vitro
nourseothricin, represents a mixture of streptothricins, mainly d and f. although very slowly, nourseothricin was found to be able to pass the outer membrane through the porin pores. it has been also shown that nourseothricin was able to generate some channels into the outer membrane. moreover, resistant strains containing a streptothricin-inactivating acetyl transferase exhibited an additional protecting system, namely a reduced penetrability of the outer membrane. in addition, such strains indeed could be rendered sensitive via damaging the barrier function of the outer membrane [1].
in vivo
animal study showed that nourseothricin was preferentially excreted via kidney and signs of nephrotoxicity could be seen. renal handling of nourseothricin was characterized on renal cortical slices under various experimental conditions. following administration the renal tubular transport system for organic anions was not influenced by nourseothricin. there was a high degree of accumulation of nourseothricin in renal cortical slices. in contrast to pah accumulation, there was no influence of nitrogen atmosphere, probenecid or trishydroxyaminomethane on nourseothricin accumulation. age dependent differences in nourseothricin accumulation did not exist [2].
Einzelnachweise
[1] seltmann g. resistance of escherichia coli to nourseothricin (streptothricin): sensitization of resistant strains by abolition of its outer membrane resistance. zentralbl bakteriol. 1992 jan;276(2):143-51.
[2] brunlich h, hoffmann h, bocker h. renal handling of nourseothricin. pharmazie. 1988 mar;43(3):200-2.

NOURSEOTHRICIN SULFATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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