Dimevamid

Bezeichnung:Dimevamid

CAS-Nr60-46-8

Englisch Name:AMINOPENTAMIDE SULFATE (200 MG)

CBNumberCB8501624

SummenformelC19H24N2O

Molgewicht296.41

MOL-Datei60-46-8.mol

Synonyma

Dimevamid

Dimevamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	178-179℃
Siedepunkt	438°C (rough estimate)
Dichte	1.069±0.06 g/cm3 (20 ºC 760 Torr)
Brechungsindex	1.5600 (estimate)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
Löslichkeit	Methanol (Slightly), Water (Slightly)
pka	15.73±0.50(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Stabilität	Hygroscopic

Gefahreninformationscode (GHS)

AMINOPENTAMIDE SULFATE (200 MG) Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Centrine,Bristol,US,1953
Verwenden
Aminopentamide Sulfate affects gastric function and gastroduodenal ulcus. Used in the treatment of vomiting, diarrhea and other side effects in dogs/cats.
Definition
ChEBI: 4-(dimethylamino)-2,2-diphenylpentanamide is a diarylmethane.
Manufacturing Process
A mixture of 14 g (0.05 mol) of α,α-diphenyl-γ-dimethylaminovaleronitrile, 16 g (0.2 mol) of sodium acetate, 14 g (0.2 mol) of hydroxylamine hydrochloride and 75 ml of ethyl alcohol was refluxed 18 hours. The mixture was cooled, poured into water and neutralized with ammonium hydroxide. The heavy white precipitate solidified on standing. The material was filtered and recrystallized from isopropanol. After three recrystallizations the aminopentamide product melted at 177° to 179°C.
The product is often used as the acid sulfate which is produced as follows: 252.0 g (0.85 mol) of α,α-diphenyl-γ-dimethylaminovaleronitrile was dissolved in one liter of isopropanol, and 70 ml of concentrated sulfuric acid was added as rapidly as possible. The mixture was heated until clear, then filtered and diluted with 1,500 ml of anhydrous ethyl acetate. The solution was cooled and filtered, and the white crystalline product was dried in vacuum over P2O5.
Therapeutic Function
Anticholinergic
läuterung methode
Crystallise dimevamide from aqueous EtOH. The hydrochloride forms leaflets from EtOH/Et2O with m 190-191o and is deliquescent. The picrate has m 210-211o. It is an antispasmotic. [Moffett et al. J Am Chem Soc 79 4451, 4457 1957, Beckett J Pharm Pharmacol 8 848 1956, Beilstein 14 III 1363, 14 IV 1865.]

AMINOPENTAMIDE SULFATE (200 MG) Upstream-Materialien And Downstream Produkte

Dimevamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

60-46-8, AMINOPENTAMIDE SULFATE (200 MG) Verwandte Suche:

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