2-Brom-1-ethylpyridiniumtetrafluoroborat

Bezeichnung:2-Brom-1-ethylpyridiniumtetrafluoroborat

CAS-Nr878-23-9

Englisch Name:2-Bromo-1-ethylpyridinium tetrafluoroborate

CBNumberCB8399472

SummenformelC7H9BBrF4N

Molgewicht273.86

MOL-Datei878-23-9.mol

Synonyma

2-Brom-1-ethylpyridiniumtetrafluoroborat

2-Brom-1-ethylpyridiniumtetrafluoroborat physikalisch-chemischer Eigenschaften

Schmelzpunkt	103-107 °C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Aggregatzustand	Crystalline Powder
Farbe	White
Wasserlöslichkeit	very faint turbidity
BRN	4059265
Major Application	peptide synthesis
InChI	InChI=1S/C7H9BrN.BF4/c1-2-9-6-4-3-5-7(9)8;2-1(3,4)5/h3-6H,2H2,1H3;/q+1;-1
InChIKey	YJDXVQLBIAJTHP-UHFFFAOYSA-N
SMILES	[N+]1(CC)C=CC=CC=1Br.[B-](F)(F)(F)F
CAS Datenbank	878-23-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	20/21/22-36/37/38
S-Sätze:	22-24/25-36/37/39-26
RIDADR	1759
WGK Germany	3
F	9-21
Hazard Note	Irritant
HazardClass	8
PackingGroup	III
HS Code	29333990
Speicherklasse	11 - Combustible Solids

Gefahreninformationscode (GHS)

2-Bromo-1-ethylpyridinium tetrafluoroborate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
2-Bromo-1-ethylpyridinium Tetrafluoroborate is a carboxyl activation and coupling reagent for peptide synthesis.
Verwenden
2-Bromo-1-ethyl-pyridinium tetrafluoroborate can be used as a coupling reagent for:
- The synthesis of N-methylated peptides in solution and solid phase.
- The synthesis of cyclosporin A fragment and dolastatin 15 pentapeptide moiety.
Allgemeine Beschreibung
2-Bromo-1-ethyl-pyridinium tetrafluoroborate is a coupling reagent employed in the synthesis of amides and esters through amidation and esterification reactions, respectively. It is generally prepared by the reaction of triethyloxonium tetrafluoroborate with 2bromo pyridine.
reaction suitability
reaction type: Coupling Reactions
Synthese
Procedure: trifluoroacetic acid (9.2 ml, 12.0 mg molecule) was added to a solution (3.00 g, 12.0 mg molecule) of N-Boc-N-methyl-L-leucine methyl ester (50 ml) at -20C. This mixture was heated to room temperature and stirred for 2 h. The aqueous layer was extracted with CH2Cl2 (2x) over Na2SO4 in order to structure and neutralize the carefully sat. aq. NaHCO3. the aqueous layer was extracted with CH2Cl2 (2x) and said composite organic layer was dried over Na2SO4. After solvent removal in evacuation, the free amine was dissolved in dry CH2Cl2 (50 mL) and N-Cbz-(L)-valine (3.32 g, 13.2 mmol) and DIEA (4.1 mL, 24.0 mmol) were added. Then, a small amount of BEP (3.61 g, 13.2 mmol) was added at room temperature to obtain a yellow solution. It was stirred overnight, diluted with CH2Cl2, and then washed with 1 mol /L aq. KHSO4, sataq . NaHCO3 and brine to wash. The solvent (Na2SO4) was removed after drying and the residue was purified by column chromatography (silica gel, PE:EtOAc 8:2). Dipeptide 1 (4.08 g, 10.4 mmol, 87%) was a colorless resin.

2-Bromo-1-ethylpyridinium tetrafluoroborate Upstream-Materialien And Downstream Produkte

2-Brom-1-ethylpyridiniumtetrafluoroborat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

878-23-9, 2-Bromo-1-ethylpyridinium tetrafluoroborate Verwandte Suche:

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