5-[1-Hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]salicylamidmonohydrochlorid

Bezeichnung:5-[1-Hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]salicylamidmonohydrochlorid

CAS-Nr32780-64-6

Englisch Name:Labetalol hydrochloride

CBNumberCB8334888

SummenformelC19H25ClN2O3

Molgewicht364.87

MOL-Datei32780-64-6.mol

Synonyma

5-[1-Hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]salicylamidmonohydrochlorid

5-[1-Hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]salicylamidmonohydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	187-189°
storage temp.	2-8°C
Löslichkeit	H₂O: soluble
Aggregatzustand	powder
Farbe	white

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
WGK Germany	3
RTECS-Nr.	CV5376000
HS Code	2924296000
Toxizität	LD50 in male, female mice, male, female rats (mg/kg): 114, 120, 113, 107 i.p.; 47, 54, 60, 53 i.v.; 1450, 1800, 4550, 4000 orally (Shimpo)

Gefahreninformationscode (GHS)

Labetalol hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or almost white powder.
Chemische Eigenschaften
Labetalol HCl is a white or off-white crystalline powder, soluble in water. Labetalol hydrochloride injection is a clear, colorless to light yellow, aqueous, sterile, isotonic solution for intravenous (IV) injection. It has a pH range of 3.0 to 4.5. Each mL contains 5 mg labetalol hydrochloride USP, 45 mg anhydrous dextrose, 0.10 mg edetate disodium; 0.80 mg of methylparaben and 0.10 mg of propylparaben as preservatives; and citric acid monohydrate and sodium hydroxide, as necessary, to bring the solution into the pH range^[1].
Originator
Trandate,Allen and Hanburys,UK,1977
Verwenden
vasoconstrictor
Verwenden
tropane alkaloid, anticholinergic drug
Definition
ChEBI: Labetalol hydrochloride is a member of salicylamides.
Indications
Labetalol hydrochloride is indicated for the control of blood pressure in patients with severe hypertension. Labetalol hydrochloride is also used to treat severe or mild pregnancy hypertension (PIH).
Manufacturing Process
(a) 5-Bromoacetylsalicylamide (2.6 g), N-benzyl-N-(1-methyl-3-phenylpropyl) amine (4.8 g) and methyl ethyl ketone (50 ml) were heated at reflux for 40 minutes. The solvent was removed and the residue was treated with benzene. The secondary amine hydrobromide was filtered off and discarded, and the filtrate was evaporated to dryness. The residue was treated with an excess of ethanolic hydrogen chloride when 5-[N-benzyl-N-(1-methyl-3-phenylpropyl)- glycyl]-salicylamide hydrochloride (1.15 g) crystallized out, MP 139°C to 141°C.
(b) 5-[N-benzyl-N-(1-methyl-3-phenylpropyl)glycyl]-salicylamide hydrochloride (0.75 g), 10% mixture of PdO and PtO on carbon catalyst (0.1 g) and ethanol (20 ml) were shaken at room temperature and pressure with hydrogen until uptake ceased. The catalyst was filtered off and the filtrate evaporated to dryness. The residue was crystallized from ethanol to give 5-[1- hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl]salicylamide hydrochloride as a white solid (0.40 g), MP 188°C.
Trademarks
Normodyne (Schering); Trandate (Promethus).
Therapeutic Function
Alpha-adrenergic blocker, Beta-adrenergic blocker
Biologische Aktivität
labetalol hcl is a selective antagonist for the α1-adrenergic receptor and a non-selective antagonist for the β-adrenergic receptor. labetalol hcl has been used for the treatment of high blood pressure. labetalol hcl competitively targets the α1-adrenergic receptors expressed in vascular smooth muscle, thus inhibiting adrenergic stimulation on endothelial cells and vasoconstriction in peripheral blood vessels. labetalol hcl also blocks the β-adrenergic receptors in bronchial and vascular smooth muscle to counteract adrenergic stimulation. ultimately, labetalol hcl causes decreases in resting and exercise heart rates, cardiac output, as well as in both systolic and diastolic blood pressure, exherting vasodilation, as well as negative chronotropic and inotropic cardiac effects.1. national center for biotechnology information (2021). pubchem compound summary for cid 3869, labetalol. retrieved august 21, 2021.2. dage rc, hsieh cp. direct vasodilatation by labetalol in anaesthetized dogs. british journal of pharmacology, 1980, 70(2): 287-293.
Einzelnachweise
[1] Labetalol Hydrochloride[J]. Definitions, 2020. DOI:10.1002/9780470909799.ch11.

Labetalol hydrochloride Upstream-Materialien And Downstream Produkte

5-[1-Hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]salicylamidmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

32780-64-6, Labetalol hydrochloride Verwandte Suche:

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