Se-Methylselenocysteine

Bezeichnung:Se-Methylselenocysteine

CAS-Nr26046-90-2

Englisch Name:Se-Methylselenocysteine

CBNumberCB8265719

SummenformelC4H9NO2Se

Molgewicht182.08

MOL-Datei26046-90-2.mol

Se-Methylselenocysteine physikalisch-chemischer Eigenschaften

Schmelzpunkt	177 °C(dec.)
Siedepunkt	314.1±37.0 °C(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	DMSO (Slightly), Water (Slightly)
pka	2.17±0.10(Predicted)
Aggregatzustand	Powder
Farbe	White to slightly yellow
InChI	InChI=1S/C4H9NO2Se/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1
InChIKey	XDSSPSLGNGIIHP-VKHMYHEASA-N
SMILES	C(O)(=O)[C@H](C[Se]C)N
LogP	-0.043 (est)

Sicherheit

Kennzeichnung gefährlicher	T,N
R-Sätze:	23/25-33-50/53
S-Sätze:	20/21-28-45-60-61-28A
RIDADR	UN 3283 6.1/PG 2
WGK Germany	3
F	10-23
HS Code	29319090

Gefahreninformationscode (GHS)

Se-Methylselenocysteine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/25:Giftig beim Einatmen und Verschlucken.
R33:Gefahr kumulativer Wirkungen.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S20/21:Bei der Arbeit nicht essen, trinken,rauchen.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
Se-methyl selenocysteine (MSC) is a naturally occurring selenium compoundwith favourable pharmacokinetic properties andth high peroral bioavailability in humans. MSC is synthesized by plants such as garlic, astragalus, onions and broccoli. Se-methylselenocysteine has been proven to have a chemo-preventive property, which is shown by several authors via various cell culture models and animal models. It has also been shown to have anti-carcinogenic properties by inducing cell cycle arrest and apoptotic cell death. It is considered a pro-drug because the compound per se is not toxic unless it is metabolized by the enzymes Kynurenine aminotransferase 1 (KYAT1), Kynurenine aminotransferase 3 (KYAT3) and cystathionine γ-lyase (CTH). Of these, KYAT1 plays a vital role in MSC metabolism.
Chemische Eigenschaften
white to slightly yellow powder
Verwenden
2-Amino-3-methylselenyl propionic acid is an inhibitor of DMBA-induced mammary tumors.
Definition
ChEBI: Se-methyl-L-selenocysteine is an L-alpha-amino acid compound having methylselanylmethyl as the side-chain. It has a role as an antineoplastic agent. It is a Se-methylselenocysteine, a non-proteinogenic L-alpha-amino acid and a L-selenocysteine derivative. It is a conjugate base of a Se-methyl-L-selenocysteinium. It is a conjugate acid of a Se-methyl-L-selenocysteinate. It is an enantiomer of a Se-methyl-D-selenocysteine. It is a tautomer of a Se-methyl-L-selenocysteine zwitterion.
benefits
Se-methylselenocysteine (MSC) is a naturally occurring selenium compound with favorable pharmacokinetic properties and high peroral bioavailability in humans. MSC has been proven to have a chemo-preventive property, which several authors show via various cell culture models and animal models. It has also been shown to have anti-carcinogenic properties by inducing cell cycle arrest and apoptotic cell death. It is considered a pro-drug because the compound per se is not toxic unless it is metabolized by the enzymes Kynurenine aminotransferase 1 (KYAT1), Kynurenine aminotransferase 3 (KYAT3) and cystathionine γ-lyase (CTH). Of these, KYAT1 plays a vital role in MSC metabolism. KYAT1 is a PLP dependent enzyme whose main function is to cleave carbon-sulfur bonds. KYAT is a bi-functional enzyme that catalyzes transamination and β-elimination reactions with single substrates. KYAT1 metabolizes MSC into β-methylselenopyruvate (MSP) and methylselenol via transamination and β-elimination catalysis.

Se-Methylselenocysteine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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