Adenosin, N-(1-Oxobutyl)-, zyklisches 3',5'-(Hydrogen-phosphat)-2'-butanoate, Mononatriumsalz

Bezeichnung:Adenosin, N-(1-Oxobutyl)-, zyklisches 3',5'-(Hydrogen-phosphat)-2'-butanoate, Mononatriumsalz

CAS-Nr16980-89-5

Englisch Name:Bucladesine sodium

CBNumberCB8236166

SummenformelC18H25N5NaO8P

Molgewicht493.39

MOL-Datei16980-89-5.mol

Synonyma

Adenosin, N-(1-Oxobutyl)-, zyklisches 3',5'-(Hydrogen-phosphat)-2'-butanoate, Mononatriumsalz

Adenosin, N-(1-Oxobutyl)-, zyklisches 3',5'-(Hydrogen-phosphat)-2'-butanoate, Mononatriumsalz physikalisch-chemischer Eigenschaften

Schmelzpunkt	>173°C (dec.)
storage temp.	-20°C
Löslichkeit	H₂O: 50 mg/mL
Aggregatzustand	powder
Farbe	white
Merck	14,1463
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey	DBXVIQJWMFGXGO-AOTDUVMNNA-N
SMILES	O([C@@H]1[C@]2([H])OP(O)(=O)OC[C@@]2([H])O[C@H]1N1C=NC2C(=NC=NC1=2)NC(=O)CCC)C(=O)CCC.[NaH] \|&1:1,2,10,13,r\|

Sicherheit

S-Sätze:	24/25
WGK Germany	2
RTECS-Nr.	ES5055500
F	10-21
HS Code	29349990

Gefahreninformationscode (GHS)

Bucladesine sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Bucladesine sodium is a derivative of cyclic-AMP with cardiac stimulant and peripheral vasodilatory properties. It is reported to be useful in cardiac insufficiency, especially after heart surgery.
Originator
Daiichi Seiyaku; Seishin Seiyaku (Japan)
Verwenden
Bucladesine sodium is an analog of cyclic AMP that stimulates cAMP-dependent protein kinase. It has vasodilator properties and is used as a cardiac stimulant.
Definition
ChEBI: Bucladesine sodium is a 3',5'-cyclic purine nucleotide.
Application
N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt has been used:
as a medium supplement for neural crest stem cells (NCSCs) differentiation
as a component of thawing medium for cryopreserved human iPSC (induced pluripotent stem cell)-derived neurons
in serum-free Dulbecco′s modified eagle′s medium (DMEM) to induce astrocyte differentiation
Trademarks
ACTOCIN
Allgemeine Beschreibung
A cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
Biochem/physiol Actions
Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).
Lager
Store at -20°C
Einzelnachweise
1) Bartsch?et al.?(2003),?Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem.,?384?1321
2) Carranza?et al.?(1998),?Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol.,?15?511
3) Hei?et al.?(1991),?Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol.,?39?233
4) Imamura?et al.?(1998),?Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA,?95?6139
5) Xia?et al.?(2016),?Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep.,?6?20270

Adenosin, N-(1-Oxobutyl)-, zyklisches 3',5'-(Hydrogen-phosphat)-2'-butanoate, Mononatriumsalz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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