Natrium-(5Z,13E,15S)-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dien-1-oat

Bezeichnung:Natrium-(5Z,13E,15S)-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dien-1-oat

CAS-Nr61849-14-7

Englisch Name:PROSTACYCLIN SODIUM SALT

CBNumberCB8167138

SummenformelC20H33NaO5

Molgewicht376.47

MOL-Datei61849-14-7.mol

Synonyma

Natrium-(5Z,13E,15S)-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dien-1-oat

Natrium-(5Z,13E,15S)-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dien-1-oat physikalisch-chemischer Eigenschaften

Schmelzpunkt	168-170 °C
RTECS-Nr.	UK8008700
storage temp.	-20°C
Löslichkeit	H₂O: 1 mg/mL Hydrolyzes to 6-ketoprostaglandin F_1α in aqueous solution.
Aggregatzustand	powder
Farbe	white
Biologische Quelle	synthetic
Wasserlöslichkeit	Soluble to 100 mM in water
Sensitive	Moisture Sensitive
Merck	13,7967
BRN	6472195
Stabilität	Light Sensitive, Temperature Sensitive
CAS Datenbank	61849-14-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22
S-Sätze:	22-26-36
WGK Germany	3
F	3-10
HS Code	29329900

Gefahreninformationscode (GHS)

PROSTACYCLIN SODIUM SALT Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Epoprostenol is a naturally occurring prostaglandin indicated for the preservation of platelet function during cardiopulmonary bypass, prevention of platelet aggregation during charcoal hemoperfusion of patients in hepatic failure, and as an alternative to heparin during renal dialysis.
Chemische Eigenschaften
Epoprostenol is white crystalline powder
Originator
Burroughs Wellcome (United Kingdom)
Verwenden
Prostaglandin I2 sodium salt has been used:
- in the preparation of stock solution for platelet washing procedure
- as supplement in platelet-rich-plasma, for platelet preparation
- to prevent platelet activation
Verwenden
Epoprostenol is an Eicosanoid which prevents the formation of platelet plugs and is an effective vasodilator.
Manufacturing Process
Preparation of prostacyclin:
Pig aortas were stripped of adventitia, snap frozen in liquid nitrogen, crushed into a fine powder, resuspended in 0.05 M Tris buffer (pH 7.5) (1:4, w:v) andhomogenised at high speed in a Polytron (KIMENATIC, LUCERNE, SWITZERLAND) homogenizer. The homogenate was centrifuged for 15 min and the resulting supernatant centrifuged again for 5 min. The pellet was discarded, while the pellet obtained after centrifugation of the supernatant was resuspended in deionized water and lyophilized. An average yield of 150 mg of aortic microsomal powder (51% protein) per 100 g of aortic tissue was obtained.
Trademarks
Flolan (GlaxoSmithKline);CYCLO-PROSTIN.
Therapeutic Function
Platelet aggregation inhibitor, Antimetastatic
Biologische Aktivität
Epoprostenol is a potent agonist at IP prostanoid receptors. Inhibits platelet aggregation and induces vasodilation.
Biochem/physiol Actions
Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.
Lager
Desiccate at -80°C

Natrium-(5Z,13E,15S)-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dien-1-oat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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