IBERIOTOXIN Struktur

IBERIOTOXIN

Bezeichnung:IBERIOTOXIN

CAS-Nr129203-60-7

Englisch Name:IBERIOTOXIN

CBNumberCB8130448

SummenformelC179H274N50O55S7

Molgewicht4230.84786

MOL-Datei129203-60-7.mol

IBERIOTOXIN physikalisch-chemischer Eigenschaften

storage temp.	-20°C
Löslichkeit	H₂O: 1 mg/mL, clear, colorless
Aggregatzustand	Salt-free lyophilized solid
Farbe	White to off-white
Wasserlöslichkeit	Soluble to 0.70 mg/ml in water

Sicherheit

Kennzeichnung gefährlicher	T+
R-Sätze:	26/27/28
S-Sätze:	28-36/37-45
RIDADR	UN 3462 6.1/PG 2
WGK Germany	3
RTECS-Nr.	NH6107500
F	3-10

Gefahreninformationscode (GHS)

IBERIOTOXIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Verwenden
Selective probe for high-conductance calcium-activated potassium channels.
Verwenden
Iberiotoxin is a selective and reversible inhibitor of high-conductance calcium-activated potassium channel. A toxin purified from the Eastern Indian red scorpion Buthus tamulus.
Verwenden
Iberiotoxin, recombinant from Mesobuthus tamulus has been used as an inhibitor of large-conductance calcium-activated K⁺ channels to study its effect on the NLRP3 (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3) inflammasome activation in bone marrow-derived macrophages (BMDMs). It has also been used to block Ca²⁺- activated K⁺ channels to determine interleukin(IL)-1β in BMDCs following inflammasome activation.
Biologische Aktivität
iberiotoxin is a 37 amino acid peptidyl toxin isolated from the scorpion mesobuthus tamulus and was shown to selectively block large conductance ca2+-activated k+ channels(bkca) in smooth muscle cells.in single channel recordings, iberiotoxin can reversibly block outward currents mediated by bkca in excised membrane patches from bovine aortic smooth muscle with an ic50 value of 250 pm. it is also a noncompetitive, partial inhibitor of charybdotoxin binding in bovine aortic sarcolemmal membrane vesicles (ki = 250 pm).[1]. galvez a, gimenez-gallego g, reuben j p, et al. purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion buthus tamulus. the journal of biological chemisty, 1990, 265(19): 11083-11090.
Biochem/physiol Actions
The single chain peptide iberiotoxin (IbTX) is a selective and reversible inhibitor of high-conductance calcium-activated potassium channels (PK,Ca). It occurs naturally in the venom of the scorpion Buthus tamulus. IbTX also modulates the binding of charybdotoxin (CbTX) to smooth muscle sarcolemmal membranes in a non-competitive manner. IbTX is similar in size to CbTX and shares considerable sequence homology with CbTX. However, IbTX differs in its overall charge in having one fewer basic and four more acidic residues than CbTX.
Lager
-20°C (desiccate)

IBERIOTOXIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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