2-HYDROXYESTRADIOL

Bezeichnung:2-HYDROXYESTRADIOL

CAS-Nr362-05-0

Englisch Name:2-HYDROXYESTRADIOL

CBNumberCB7767256

SummenformelC18H24O3

Molgewicht288.38

MOL-Datei362-05-0.mol

2-HYDROXYESTRADIOL physikalisch-chemischer Eigenschaften

Schmelzpunkt	96-104°C
Siedepunkt	370.61°C (rough estimate)
Dichte	1.1285 (rough estimate)
Brechungsindex	1.5000 (estimate)
storage temp.	−20°C
Löslichkeit	≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
Aggregatzustand	Solid
Farbe	White to light yellow

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	40
S-Sätze:	22-36
WGK Germany	3
RTECS-Nr.	KG7675000

Gefahreninformationscode (GHS)

2-HYDROXYESTRADIOL Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Pale Yellow Solid
Verwenden
A metabolite of Estradiol
Definition
ChEBI: A 2-hydroxy steroid that consists of 17beta-estradiol having an additional hydroxy group at position 2.
Biologische Aktivität
2-hydroxyestradiol is an angiogenesis inhibitor via the hif-1a pathway.hif-1a, a basic helix-loop-helix pas domain containing protein, is reported as the master transcriptional regulator of cellular and developmental response to hypoxia.
in vitro
in vitro evidences suggested that most of the cellular effects of 2-hydroxyestradiol were mediated by 2-methoxyestradiol, a metabolite of 2-hydroxyestradiol as an anti-cancer agent acting as an angiogenesis inhibitor via the hif-1a pathway. inhibition of catechol-o-methyltransferase (comt), the enzyme methylating 2-hydroxyestradiol to 2-methoxyestradiol, blocked the ability of 2-hydroxyestradiol to inhibit growth of vascular smooth muscle cells, cardiac fibroblasts, as well as renal mesangial cells. moreover, 2-hydroxyestradiol could inhibit vascular smooth muscle cell growth in cells obtained from wild-type mice but not in cells cultured from comt knockout mice. in contrast to 2ohe, treatment of vascular smooth muscle cells with 2-methoxyestradiol inhibited serum-induced growth of cells from both wild-type and comtknockout mice [1].
in vivo
animal study showed that after administration of 2-hydroxyestradiol, plasma levels of 2-hydroxyestradiol declined extremely rapidly. concomitant with the disappearance of 2-hydroxyestradiol, 2-methoxyestradiol occurred and then declined. after administration of 2-methoxyestradiol, plasma levels of 2meoe declined with a plasma cl of 50 ml min(-1) kg(-1). we could not detect 2-hydroxyestradiol in plasma from rats receiving 2-methoxyestradiol. thus, the authors conclude that the conversion of 2-hydroxyestradiol to 2-methoxyestradiol was so efficient, and the administration of 2-hydroxyestradiol is bioequivalent to administration of 2-methoxyestradiol itself [1].
Einzelnachweise
[1] zacharia, l. c.,piché, c.a.,fielding, r.m., et al. 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. journal of pharmacology and experimental therapeutics 309(3), 1093-1097 (2004).

2-HYDROXYESTRADIOL Upstream-Materialien And Downstream Produkte

2-HYDROXYESTRADIOL Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

362-05-0, 2-HYDROXYESTRADIOL Verwandte Suche:

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