H-LEU-4M-BETANA HCL Struktur

(S)-2-Amino-N-(4-methoxy-2-naphthyl)-4-methylvaleramidmonohydrochlorid

Bezeichnung:(S)-2-Amino-N-(4-methoxy-2-naphthyl)-4-methylvaleramidmonohydrochlorid

CAS-Nr4467-68-9

Englisch Name:H-LEU-4M-BETANA HCL

CBNumberCB7743373

SummenformelC17H23ClN2O2

Molgewicht322.83

MOL-Datei4467-68-9.mol

Synonyma

(S)-2-Amino-N-(4-methoxy-2-naphthyl)-4-methylvaleramidmonohydrochlorid

(S)-2-Amino-N-(4-methoxy-2-naphthyl)-4-methylvaleramidmonohydrochlorid physikalisch-chemischer Eigenschaften

storage temp.	2-8°C
Löslichkeit	≤25mg/ml in ethanol;10mg/ml in DMSO;20mg/ml in dimethyl formamide
Aggregatzustand	crystalline solid

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	40
S-Sätze:	22-36
WGK Germany	3

Gefahreninformationscode (GHS)

H-LEU-4M-BETANA HCL Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
L-Leucine 4-methoxy-β-naphthylamide is a cell-permeable substrate for aminopeptidase M and leucine aminopeptidase that was developed for intracellular analysis of protease activities.
Chemische Eigenschaften
Crystalline
Verwenden
L-Leucine 4-methoxy-β-naphthylamide is a cell-permeable substrate for aminopeptidase M and leucine aminopeptidase that was developed for intracellular analysis of protease activities.
in vitro
l-leucine 4-methoxy-β-naphthylamide was identified as a cell-permeable substrate for aminopeptidase m and leucine aminopeptidase that was developed for intracellular analysis of protease activities [1]. in a previous method-developing study, peptide derivatives of 4-methoxy-β-naphthylamine including l-leucine 4-methoxy-β-naphthylamide were incubated in microtiter plates together with nitrosalicylaldehyde. selectivity was achieved by running parallel assays containing inhibitors partially selective for each of peptide derivatives. this method was successfully validated by measurements in cells isolated from cathepsin b-/--, k-/--, and l-/-- mice [2].
Einzelnachweise
[1] monis, b. ,wasserkrug, h. and seligman, a.m. comparison of fixatives and substrates for aminopeptidase. journal of histochemistry and cytochemistry 13(6), 503-509 (1965).
[2] rüttger, a. ,mollenhauer, j.,lser, r., et al. microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-β-naphthylamide. biotechniques 41(4), 469-473 (2006).

(S)-2-Amino-N-(4-methoxy-2-naphthyl)-4-methylvaleramidmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

4467-68-9, H-LEU-4M-BETANA HCL Verwandte Suche:

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