Formoterol

Bezeichnung:Formoterol

CAS-Nr73573-87-2

Englisch Name:Formoterol

CBNumberCB7722411

SummenformelC19H24N2O4

Molgewicht344.4

MOL-Datei73573-87-2.mol

Formoterol physikalisch-chemischer Eigenschaften

Siedepunkt	603.2±55.0 °C(Predicted)
Dichte	1.233±0.06 g/cm3(Predicted)
Löslichkeit	DMSO: 20 mg/mL, soluble
Aggregatzustand	solid
pka	8.95±0.50(Predicted)
Farbe	off-white
Stabilität	Stable. Incompatible with strong oxidizing agents.
CAS Datenbank	73573-87-2(CAS DataBase Reference)

Sicherheit

WGK Germany	3
Giftige Stoffe Daten	73573-87-2(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Formoterol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Formoterol is a potent bronchoselective β-agonist with long duration of action given by inhalation.
Chemische Eigenschaften
solid
Verwenden
Labeled Formoterol, intended for use as an internal standard for the quantification of Formoterol by GC- or LC-mass spectrometry.
Verwenden
Formoterol is a useful compound for treating respiratory obstructive diseases.
Definition
ChEBI: A phenylethanoloamine having 4-hydroxy and 3-formamido substituents on the phenyl ring and an N-(4-methoxyphenyl)propan-2-yl substituent.
Trademarks
Foradil (Novartis).
Allgemeine Beschreibung
Formoterol (Foradil) isalso a lipophilic (log P= 1.6) and long-acting β2-agonist. Ithas 3'-formylamino ( β-directing) and 4 OH groups on onephenyl ring and a lipophilic -directing N-isopropyl-pmethoxyphenylgroup on the nitrogen atom. Its long DOA(12 hours), which is comparable to that of salmeterol, hasbeen suggested to result from its association with the membranelipid bilayer, from which it gradually diffuses to provideprolonged stimulation of β2 receptors and its resistanceto MAO and COMT. Formoterol has a much faster onset ofaction than does salmeterol as result of its lower lipophilicity.Both of these long-acting drugs are used by inhalationand are recommended for maintenance treatment of asthma,usually in conjunction with an inhaled corticosteroid.
Mechanism of action
Formoterol has 3′-formylamino and 4′-hydroxy ring R3 substitution pattern but also an alkoxyphenylethyl lipophilic group R1 on the nitrogen, similar to ritodrine. Although it is less lipophilic (log P = 1.6) than salmeterol, it has a 12-hour duration of action similar to that for salmeterol. It is administered as an inhaled dry powder, because it is unstable to heat and moisture. It is a mixture of (R,R)-(–)- and (S,S)-(+)-stereoisomers, with the (R,R)-isomer having approximately 1,000-fold more affinity for the β2-receptor than the (S,S)-isomer. Because of its high potency and low dose, however, there is no clinical advantage for using (R,R)-formoterol as bronchodilator compared to the racemate. Unlike salmeterol, formoterol has a faster onset of action as a result of its lower lipophilicity. It is also more potent; a 12-μg dose of formoterol has been demonstrated to be equivalent to a 50-μg dose of salmeterol.

Formoterol Upstream-Materialien And Downstream Produkte

Formoterol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

73573-87-2, Formoterol Verwandte Suche:

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