(+)METHAMPHETAMINE HYDROCHLORIDE Struktur

Methamphetaminhydrochlorid

Bezeichnung:Methamphetaminhydrochlorid

CAS-Nr51-57-0

Englisch Name:(+)METHAMPHETAMINE HYDROCHLORIDE

CBNumberCB7717701

SummenformelC10H16ClN

Molgewicht185.69

MOL-Datei51-57-0.mol

Synonyma

Methamphetaminhydrochlorid

Methamphetaminhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	166-168?C
alpha	D25 +14 to +20°
Flammpunkt	9°C
storage temp.	Controlled Substance, -20°C Freezer
EPA chemische Informationen	Methamphetamine hydrochloride (51-57-0)

Sicherheit

Kennzeichnung gefährlicher	T,F
R-Sätze:	25-39/23/24/25-23/24/25-11
S-Sätze:	45-36/37-16
RIDADR	3249
WGK Germany	2
RTECS-Nr.	SH5455000
HazardClass	6.1(b)
PackingGroup	III
HS Code	2939710000
Toxizität	LD50 i.p. in mice: 70 mg/kg (Lands)

Gefahreninformationscode (GHS)

(+)METHAMPHETAMINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
(+)-Methamphetamine (Item No. 13997) is an analytical reference material categorized as an amphetamine. It is the more physiologically active isomer of (±)-methamphetamine and is both neurotoxic and frequently abused. Methamphetamine is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Chemische Eigenschaften
Off-White Solid
Originator
Desoxyn ,Abbott Laboratories
Verwenden
A CNS stimulant. Anorexic. In attention deficit disorder with hyperactivity. Controlled substance (stimulant).
Definition
ChEBI: A hydrochloride having methamphetamine as the base component.
Manufacturing Process
2 Methods of prepearing of methamphetamine:
1. (-)-Ephedrin was reduced by hydrogenesation with hydrogen in the presence of Pt-C catalyst to give the (+)-N-α-dimethylphenethylamine (methamphetamine), melting point 172°-174°C.
2. Methamphetamine was obtained by the methylation of phenylisopropylamine.
To give methamphetamine hydrochloride the base methamphetamine was treated by eqimolar quantity of hydrochloric acid.
Therapeutic Function
Sympathomimetic, Central stimulant
Allgemeine Beschreibung
Methamphetamine, (+)-1-phenyl-2-methylaminopropanehydrochloride desoxyephedrine hydrochloride (Desoxyn), isthe N-methyl analog of dextroamphetamine. It has moremarked central and less peripheral action than dextroamphetamine.It has a very high abuse potential, and by the intravenousroute, its salts are known as “speed.” The overallabuse problem presented by the drug is a national disaster.Medicinally acceptable uses of methamphetamine are analogousto those of dextroamphetamine.
Biochem/physiol Actions
Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.
Sicherheitsprofil
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits toxic fumes of NOx and HCl. See also BENZEDRINE and various amphetamines.

(+)METHAMPHETAMINE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

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