Ginkgolic acid

Bezeichnung:Ginkgolic acid

CAS-Nr22910-60-7

Englisch Name:Ginkgolic acid

CBNumberCB7673186

SummenformelC22H34O3

Molgewicht346.5

MOL-Datei22910-60-7.mol

Ginkgolic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	45～48℃
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	White solid
Siedepunkt	221-223 °C(Press: 4 Torr)
Dichte	0.9148 g/cm3
pka	3.08±0.30(Predicted)
Farbe	White to Off-White
InChIKey	YXHVCZZLWZYHSA-FPLPWBNLSA-N
LogP	9.269 (est)
CAS Datenbank	22910-60-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	22-24/25-26
WGK Germany	3
HS Code	29182900

Gefahreninformationscode (GHS)

Ginkgolic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Ginkgolic acid is slightly toxic and is an allergen; for this reason, some sources suggest using only the standardized extract, which is standardized to the flavonoids and minimizes ginkgolic acid content.
Ginkgolic acid is active against the tubercle bacillus. Elsewhere, leaf extracts are used in peripheral arterial circulation problems like arteriosclerotic angiopathy, post-thrombotic syndrome, diabetic vasoconstriction with gangrene and angina, intermittent claudication，Raynaud's disease. Extracts are inhaled for ear, nose, and throat ailments like bronchitis and chronic rhinitis.
Extracts of the leaves and fruit of Ginkgo plants have long been used in traditional medicine and have multiple potential therapeutic applications, including ameliorating dementia. However, ginkgolic acids, 2-hydroxy-6-alkylbenzoic acids related to anacardic acids, may be deleterious components in these extracts. Ginkgolic acid C15:1 is a 2-hydroxy-6-alkylbenzoic acid in which the alkyl chain contains 15 carbons and is unsaturated at the 8 position. It inhibits SUMOylation in vitro (IC50 = 3 μM) and in cells without affecting protein ubiquitination. Ginkgolic acid C15:1 directly binds the SUMO-activating enzyme E1, blocking the formation of the E1-SUMO intermediate. Ginkgolic acid C15:1 also suppresses the development of pancreatic cancer xenografts in mice.
Verwenden
Ginkgolic acid C15:1 may be used as a reference standard in the quantitative determination of alkylphenols like ginkgolic acids in Ginkgolic extract using high performance liquid chromatography coupled with mass spectrometry(HPLC-MS).
Ginkgolic acid C15:1 may be used as an analytical reference standard for the quantification of the analyte in Ginkgo biloba plant extracts, and dietary supplements using chromatography techniques.
Definition
ChEBI:Ginkgoic acid is a hydroxybenzoic acid. It derives from a salicylic acid.
Allgemeine Beschreibung
Ginkgolic acid C15:1 is an alkylphenol belonging to the class of ginkgolic acids isolated from Ginkgo biloba leaves. It also shows strong allergenic properties, with carcinogenic and mutagenic activity.
Biochem/physiol Actions
Cell permeable: yes

Ginkgolic acid Upstream-Materialien And Downstream Produkte

Ginkgolic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

22910-60-7, Ginkgolic acid Verwandte Suche:

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