ETHCHLORVYNOL CIV (0.7 ML)

Bezeichnung:ETHCHLORVYNOL CIV (0.7 ML)

CAS-Nr113-18-8

Englisch Name:ETHCHLORVYNOL CIV (0.7 ML)

CBNumberCB7500514

SummenformelC7H9ClO

Molgewicht144.6

MOL-Datei113-18-8.mol

ETHCHLORVYNOL CIV (0.7 ML) physikalisch-chemischer Eigenschaften

Schmelzpunkt	25°C
Siedepunkt	bp760 173-174°; also reported as bp760 181°; bp0.1 28.5-30°
Dichte	d425 1.065-1.070; also reported as d420 1.070
Brechungsindex	nD25 1.4675-1.4800
Löslichkeit	Chloroform (Soluble), Methanol (Slightly)
Aggregatzustand	Oil
pka	12.06±0.29(Predicted)
Farbe	Colourless

Sicherheit

HS Code	2905510000
Giftige Stoffe Daten	113-18-8(Hazardous Substances Data)
Toxizität	LD50 in mice (mg/kg): 290 orally; 240 s.c. (P'an)

Gefahreninformationscode (GHS)

ETHCHLORVYNOL CIV (0.7 ML) Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Clear Colorless Oil
Originator
Placidyl,Abbott,US,1965
Verwenden
Controlled substance (depressant). Sedative; hypnotic.
Definition
ChEBI: Propargyl alcohol in which the methylene hydrogens are substituted by ethyl and 2-chlorovinyl groups. A hypnotic and sedative, it is used for treatment of insomnia in some cases where an intolerance or allergy to more commonly used drugs exists.
Manufacturing Process
Acetylene was passed into a stirred solution of 3.05 grams (0.44 mol) of lithium in 300 ml of liquid ammonia until the blue color exhibited by the mixture had disappeared. Ethyl β-chlorovinyl ketone (47.4 grams; 0.40 mol) dissolved in 50 ml dry ether was then added to the resulting solution of lithium acetylide over a period of 20 minutes, during which the color deepened through yellow to reddish-brown. The mixture was stirred under reflux maintained with a Dry Ice condenser for 2 hours. Thereafter, dry ether (200 ml) was added and the ammonia was permitted to evaporate with stirring overnight.
The residue was poured into a slurry of ice and water containing 30 grams (0.50 mol) of acetic acid. After separating the ether layer, the aqueous layer was washed with two 200 milliliter portions of ether. The combined ether extracts were washed with saturated sodium bicarbonate solution, dried over anhydrous magnesium sulfate and evaporated in a stream of pure nitrogen. Three successive distillations of the residue gave 46.3 grams (80.2% yield) of a colorless liquid, boiling point 28.5° to 30°C at 0.1 mm Hg.
Trademarks
Placidyl (Abbott).
Therapeutic Function
Sedative, Hypnotic
Sicherheitsprofil
Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Human systemic effects by ingestion: general anesthesia and thrombocytopenia (reduction in the number of blood platelets). Human effects on newborn by an unspecified route: drug dependency and Apgar score (condtion of newborn). Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of Cl-.

ETHCHLORVYNOL CIV (0.7 ML) Upstream-Materialien And Downstream Produkte

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