Benzhydrylamin

Bezeichnung:Benzhydrylamin

CAS-Nr91-00-9

Englisch Name:Benzhydrylamine

CBNumberCB7409604

SummenformelC13H13N

Molgewicht183.25

MOL-Datei91-00-9.mol

Synonyma

Benzhydrylamin

Benzhydrylamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	12 °C (lit.)
Siedepunkt	295 °C (lit.)
Dichte	1.063 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.595(lit.)
Flammpunkt	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
Löslichkeit	Chloroform, DMSO, Methanol
Aggregatzustand	Liquid
pka	8.41±0.10(Predicted)
Wichte	1.063
Farbe	Clear colorless to yellow
Wasserlöslichkeit	Miscible with chloroform, dimethylsulfoxide and methanol. Slightly miscible with water.
Sensitive	Air Sensitive
Merck	14,1076
BRN	776434
CAS Datenbank	91-00-9(CAS DataBase Reference)
NIST chemische Informationen	Aminodiphenylmethane(91-00-9)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38
S-Sätze:	26-36
RIDADR	2810
WGK Germany	3
RTECS-Nr.	DA4407300
F	9-23
HazardClass	8
PackingGroup	III
HS Code	29214990

Gefahreninformationscode (GHS)

Benzhydrylamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Colorless liquid
Verwenden
Benzhydrylamine is fine-chemical intermediate used for chiral resolution. It acts as an active pharmaceutical ingredient intermediate. It is also employed as a building block for chemical synthesis. Further, it is used in the preparation of furan-2-carboxylic acid benzhydrylamide by reacting with furan-2-carbonyl chloride.
Synthesis Reference(s)
Tetrahedron Letters, 27, p. 3033, 1986 DOI: 10.1016/S0040-4039(00)84709-7
Synthese
1) synthesis of diphenylketoxime
After benzophenone 10g, oxammonium hydrochloride 6g, 95% ethanol 20mL are put into reaction flask stirring and dissolving, gradation adds sodium hydrate solid 11g.Finish, reaction solution is heated to 88 DEG C of reaction 2h, then pours in dilute hydrochloric acid solution by reaction solution, occurs white solid, filter to obtain diphenylketoxime 10.7g, yield 99%.
2) synthesis of benzhydrylamine
Diphenylketoxime 0.25g, 95% ethanol 5mL are put into reaction flask, after solution change is clear, adds concentration into 5 × 10 7cFU/mL waxy Bacillus solution 50mL, constant temperature 30 DEG C (rotating speed 200r/min) oscillatory reaction in shaking table.TLC detect without raw material time, add appropriate diatomite in reaction solution and carry out centrifugation, get supernatant liquid acidifying, with dichloromethane extraction, aqueous layer basified and with dichloromethane extraction concentrate to obtain benzhydrylamine 9.0g, yield 91%.
läuterung methode
Crystallise the amine from H2O. The free base absorbs CO2 from the atmosphere; store it accordingly. The hydrochloride M 219.7 m 293-295o, crystallises from H2O. [Beilstein 12 H 1323, 12 IV 3282.]

Benzhydrylamine Upstream-Materialien And Downstream Produkte

Benzhydrylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

91-00-9, Benzhydrylamine Verwandte Suche:

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