Meticran

METICRANE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Fontilix,Diamant

• Verwenden

  diuretic, antihypertensive

• Definition

  ChEBI: Meticrane is a thiochromane.

• Manufacturing Process

  64.5 g of 6-methylthiachromane were dissolved in 500 ml of acetic acid and 250 ml of 110-volume hydrogen peroxide were added. The solution was placed on a water bath for 1.5 hour; it was then diluted with iced water, the precipitate obtained was recovered, and this was washed and dried. There were obtained 59.6 g of 6-methylthiachromane-1,1-dioxide (yield: 77.5%; melting point 79°-81°C).
  52 g of this product were added to 250 ml of chlorosulfonic acid and the mixture was placed on a water bath at a temperature of 70°-75°C for 2 hours. It was allowed to cool and poured onto crushed ice; the product was extracted by means of chloroform, the extracted solutions were washed and the chloroform was evaporated. There were obtained 67 g of crude 6-methyl- 7-chloro-sulfonyl-thiachromane-1,1-dioxide (yield: 86%; melting point 158°- 161°C).
  47 g of this sulfochloride were introduced into 200 ml of liquid ammonia. The mixture was left to stand at ambient temperature until the ammonia evaporated. The residue was taken up in water and the solution was acidified. The precipitate formed was centrifuged, washed with water and dried. There were obtained 30.8 g of 6-methyl-7-sulfamido-thiachromane-1,1-dioxide, recrystallized from 2-methoxy ethanol (yield: 49%; MP: 236°-237°C).

• Therapeutic Function

  Diuretic

METICRANE Upstream-Materialien And Downstream Produkte

Meticran Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(60)Suppliers

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