2,5-Dibrompyridin

Bezeichnung:2,5-Dibrompyridin

CAS-Nr624-28-2

Englisch Name:2,5-Dibromopyridine

CBNumberCB7283491

SummenformelC5H3Br2N

Molgewicht236.89

MOL-Datei624-28-2.mol

Synonyma

2,5-Dibrompyridin

2,5-Dibrompyridin physikalisch-chemischer Eigenschaften

Schmelzpunkt	92-95 °C (lit.)
Siedepunkt	235 °C / 772mmHg
Dichte	2.0383 (rough estimate)
Brechungsindex	1.5800 (estimate)
Flammpunkt	62℃
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Crystalline Powder
pka	-1.57±0.10(Predicted)
Farbe	Almost white or light beige to brown
Wasserlöslichkeit	insoluble
BRN	109099
InChI	InChI=1S/C5H3Br2N/c6-4-1-2-5(7)8-3-4/h1-3H
InChIKey	ZHXUWDPHUQHFOV-UHFFFAOYSA-N
SMILES	C1(Br)=NC=C(Br)C=C1
CAS Datenbank	624-28-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-20/21/22
S-Sätze:	26-37/39-36/37/39-36
RIDADR	UN2811
WGK Germany	3
HazardClass	IRRITANT
HS Code	29333999

Gefahreninformationscode (GHS)

2,5-Dibromopyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Pyridine and its derivatives are distributed widely by nature. Many plant constituents are as contain pyridine ring compounds in the structure of alkaloids, etc.; they are the bases producing many vital compounds and are indispensable raw materials during medicine, agricultural chemicals, dyestuff, tension-active agents, rubber ingredients, fodder additives, foodstuff additives, tackiness agents, etc. are produced.2,5-dibromo pyridine is an important intermediate of organic synthesis and is mainly used in medicine intermediate, organic synthesis, and organic solvent, can also be applicable to aspects such as DYE PRODUCTION, pesticide production and spices. Selective monolithiation of 2,5-dibromopyridine at either the 2-position or the 5-position is reported. Solvent and concentration strongly influence the selectivity. Coordinating solvents and higher concentration favour the 5-position, while non-coordinating solvents and lower concentration favour the 2-position[1].
Chemische Eigenschaften
2,5-Dibromopyridine is an off-white crystalline solid. It is insoluble in water but soluble in strong polar organic solvents. It exhibits strong alkalinity.
Verwenden
2,5-Dibromopyridine (cas# 624-28-2) is a compound useful in organic synthesis.
synthetische
To synthesize 2,5-dibromopyridine, follow these steps:
Add 2-amino-5-bromopyridine (13.0 kg) into a water-cooled solution at 10 °C.
Slowly add 47% aqueous hydrogen bromide (37 L) to the mixture.
Introduce liquid bromine (11 L) into the mixture.
Maintain the reaction temperature below 10 °C.
Prepare a solution of NaNO2 (16.1 kg) and H2O (19 L) and add it dropwise to the mixture while keeping the temperature between 0-5 °C.
Stir the reaction mixture for 30 minutes.
Treat the mixture with a solution of NaOH (28.0 kg) in water (30 L) at a controlled rate below 20-25 °C.
Extract the reaction mixture with diethyl ether (3 × 40 L).
Dry the organic layer with anhydrous Na2SO4.
Remove the desiccant by filtration.
Evaporate the resulting filtrate under reduced pressure to dryness.
Suspend the residue in heptane (10 L).
Collect the target product molecule, 2,5-dibromopyridine, by filtration.
Synthesis method of 2,5-dibromopyridine
Einzelnachweise
[1] Xin Wang. “Selective monolithiation of 2,5-dibromopyridine with butyllithium.” Tetrahedron Letters 41 1 (2000): 4335–4338.

2,5-Dibromopyridine Upstream-Materialien And Downstream Produkte

2,5-Dibrompyridin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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