Vortioxetine hydrobromide

Bezeichnung:Vortioxetine hydrobromide

CAS-Nr960203-27-4

Englisch Name:Vortioxetine hydrobromide

CBNumberCB72614372

SummenformelC18H23BrN2S

Molgewicht379.36

MOL-Datei960203-27-4.mol

Vortioxetine hydrobromide physikalisch-chemischer Eigenschaften

Schmelzpunkt	>223°C (dec.)
storage temp.	Refrigerator
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	Pale Beige to Light Beige
InChI	InChI=1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H
InChIKey	VNGRUFUIHGGOOM-UHFFFAOYSA-N
SMILES	S(C1C=CC(C)=CC=1C)C1C=CC=CC=1N1CCNCC1.Br

Sicherheit

HS Code

29339900

Gefahreninformationscode (GHS)

Bildanzeige (GHS)
Alarmwort

Warnung
Gefahrenhinweise

H302：Gesundheitsschädlich bei Verschlucken.

H317：Kann allergische Hautreaktionen verursachen.

H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.
Sicherheit

P261：Einatmen von Staub vermeiden.

P264：Nach Gebrauch gründlich waschen.

P264：Nach Gebrauch gründlich waschen.

P270：Bei Gebrauch nicht essen, trinken oder rauchen.

P272：Kontaminierte Arbeitskleidung nicht außerhalb des Arbeitsplatzes tragen.

P273：Freisetzung in die Umwelt vermeiden.

P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

P321：Besondere Behandlung

P330：Mund ausspülen.

P333+P313：Bei Hautreizung oder -ausschlag: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

P363：Kontaminierte Kleidung vor erneutem Tragen waschen.

P391：Verschüttete Mengen aufnehmen.

P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Vortioxetine hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Vortioxetine Hydrobromide is a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3).
Definition
ChEBI: Vortioxetine hydrobromide is a hydrobromide obtained by combining vortioxetine with one molar equivalent of hydrobromic acid. Used for treatment of major depressive disorder. It has a role as an antidepressant, an anxiolytic drug, a serotonergic antagonist and a serotonergic agonist. It contains a vortioxetine(1+).
Biologische Aktivität
vortioxetine (lu aa21004) hbr (vortioxetine) is an antidepressant, [1] [2] and a serotonin (5-ht) receptor modulator [1] [3] with ki values of 3.7 nm, 19 nm, 200 nm, 33 nm, 15 nm, and 1.6 nm, to human (h) 5-ht3a receptor, h5-ht7 receptor, rat (r) 5-ht7 receptor, h5-ht1b receptor, h5-ht1a receptor and h5-ht transporter (hsert), respectively, with an ic50 value of 2080 nm to r5-ht7 receptor, and with an ec50 value of 460 nm to h5-ht1b receptor [3].5-ht is important in brain, acting as a neurotransmitter in neuromodulation [4].in hela cells expressing h5-ht1b receptors stably, lu aa21004 displayed a partial agonistic response with an ec50 value of 460±110 nm and an ia of 22%. in a polyclonal hek-293 cell line expressing the r5-ht7 receptor, lu aa21004 bound to the r5-ht7 receptor with a ki value of 200±27 nm and was a functional antagonist at the r5-ht7 receptor with an ic50 value of 2080±18 nm [3].in rats, subcutaneous (sc) administration of lu aa21004 resulted in ed50 values of 0.4 mg/kg and 3.2 mg/kg to the rsert and the r5-ht1b receptor, respectively. lu aa21004 acted as an antagonist of 5-ht3 receptor with an ed50 value of 0.11 mg/kg sc [3]. treatment with vortioxetine at doses of 2.5 and 5 mg/kg prior to the acquisition of novel objects made rats show 29 and 33 s, respectively, as average exploration values [5].
Synthese
As the picture 2 showed, we have developed a new and practical synthetic route to vortioxetine hydrobromide on a hectogram scale. Adopting commercially available materials, through simple and traditional steps, including nucleophilic substitution, catalytic hydrogenation, and cyclization of the piperazine ring, gave the final product in 63.2% yield over three steps and with 99.3% purity (HPLC). Purification methods for the intermediates involved in the route are also given.

Pic.3 A new synthetic route to vortioxetine hydrobromide
Solubility in water
Vortioxetine hydrobromide is slightly soluble in water; at ambient temperature solubility is equivalent to approximately 1.3 mg base/mL, pH being 5.5 in the saturated solution.
Mode of action
Vortioxetine Hydrobromide is a hydrobromide salt form of vortioxetine, a serotonin (5-HT) modulator and stimulator (SMS), with antidepressant activity. Vortioxetine inhibits the reuptake of serotonin and norepinephrine from the synaptic cleft and acts variably as a serotonin receptor agonist (5-HT1A), partial agonist (5-HT1B) or antagonist (5-HT3, 5-HT1D and 5-HT7). It is not clear how this agent's purported multimodal mechanism of action contributes to its antidepressant effect; however, it is presumed to increase the synaptic availability of serotonin and norepinephrine.
Vorsichtsmaßnahmen
Vortioxetine is a serotonergic drug that has a risk of causing serotonin syndrome, especially when combined with other serotonergic drugs such as SSRIs, SNRIs, TCAs, or MAOIs.
Vortioxetine has been known to cause an increase in the risk of bleeding because of interference with serotonin reuptake. The concomitant use of NSAIDs, aspirin, warfarin, and anticoagulants may increase the risk of abnormal bleeding.
Among patients using vortioxetine, reports of symptoms of mania/hypo-mania were less than 0.1%. However, this drug should be used with caution in patients with a personal or family history of bipolar disorder, mania, or hypomania.
Hyponatremia was reported in one patient taking vortioxetine. Hyponatremia is related to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Elderly patients are at higher risk for hyponatremia, as well as patients taking diuretics. Vortioxetine should be discontinued if signs and symptoms of hyponatremia are present and if there is a decrease in sodium levels[6].
Einzelnachweise
[1]. connie sanchez, karen e. asin, francesc artigas, et al. vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. pharmacology & therapeutics, 2015, 145:43-57.
[2]. er-min gu, chengke huang, bingqing liang, et al. an uplc–ms/ms method for the quantitation of vortioxetine in rat plasma: application to a pharmacokinetic study. j. chromatogr. b, 2015, 997:70-74.
[3]. a. mørk, a. pehrson, l.t. brennum, s. møller nielsen, et al. pharmacological effects of lu aa21004: a novel multimodal compound for the treatment of major depressive disorder. j. pharmacol. exp. ther., 2012, 340:666-675.
[4]. david m. lovinger. serotonin’s role in alcohol’s effects on the brain. alcohol health & research world, 1997, 21(2):114-120.
[5]. arne mørk, liliana p. montezinho, silke miller, et al. vortioxetine (lu aa21004), a novel multimodal antidepressant, enhances memory in rats. pharmacology, biochemistry and behavior, 2013, 105:41-50.
[6] Andrew, et al. "Vortioxetine (brintellix): a new serotonergic antidepressant. "P & T : a peer-reviewed journal for formulary management(2015).

Vortioxetine hydrobromide Upstream-Materialien And Downstream Produkte

Vortioxetine hydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

960203-27-4, Vortioxetine hydrobromide Verwandte Suche:

Send Inquriy