ALPHA-ENDORPHIN

Bezeichnung:ALPHA-ENDORPHIN

CAS-Nr59004-96-5

Englisch Name:ALPHA-ENDORPHIN

CBNumberCB7261017

SummenformelC77H120N18O26S

Molgewicht1745.95

MOL-Datei59004-96-5.mol

ALPHA-ENDORPHIN physikalisch-chemischer Eigenschaften

RTECS-Nr.	JZ2270000
storage temp.	−20°C
Löslichkeit	≥174.5 mg/mL in DMSO; insoluble in EtOH; ≥52.7 mg/mL in H2O
Aggregatzustand	White powder
Stabilität	Hygroscopic

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
F	10

ALPHA-ENDORPHIN Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
An opioid peptide and substrate for transglutaminase
Biologische Aktivität
endorphins are endogenous opioid peptides that function as neurotransmitters(1). they are produced by the pituitary gland and the hypothalamus in vertebrates during exercise, excitement, pain, consumption of spicy food, love and orgasm, and they resemble the opiates in their abilities to produce analgesia and a feeling of well-being.the term implies a pharmacological activity (analogous to the activity of the corticosteroid category of biochemicals) as opposed to a specific chemical formulation. it consists of two parts: endo- and -orphin; these are short forms of the words endogenous and morphine(2), beta-endorphin (β-endorphin) is released into blood from the pituitary gland and into the spinal cord and brain from hypothalamic neurons. the β-endorphin that is released into the blood cannot enter the brain in large quantities because of the blood–brain barrier, so the physiological importance of the β-endorphin that can be measured in the blood is far from clear. β-endorphin is a cleavage product of pro-opiomelanocortin (pomc), which is also the precursor hormone for adrenocorticotrophic hormone (acth). the behavioural effects of β-endorphin are exerted by its actions in the brain and spinal cord, and it is presumed that the hypothalamic neurons are the major source of β-endorphin at these sites. in situations where the level of acth is increased (e.g., cushing’s syndrome), the level of endorphins also increases slightly(3).figure1 formula of a-endorphinfigure 2 mechanism of endorphin to inhibit lhrh release
Einzelnachweise
1. Oswald Steward: Functional neuroscience (2000), page 116.2. Goldstein A, Lowery PJ (September 1975). "Effect of the opiate antagonist naloxone on body temperature in rats". Life Sciences 17 (6): 927–31.3. Simantov R, Snyder S (1976). "Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor". Proc Natl Acad Sci USA 73 (7): 2515–9.

ALPHA-ENDORPHIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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