Trolox Struktur

6-Hydroxy-2,5,7,8-tetramethylchroman-2-carbonsure

Bezeichnung:6-Hydroxy-2,5,7,8-tetramethylchroman-2-carbonsure

CAS-Nr53188-07-1

Englisch Name:Trolox

CBNumberCB7188583

SummenformelC14H18O4

Molgewicht250.29

MOL-Datei53188-07-1.mol

Synonyma

6-Hydroxy-2,5,7,8-tetramethylchroman-2-carbonsure

6-Hydroxy-2,5,7,8-tetramethylchroman-2-carbonsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	187-189 °C (lit.)
Siedepunkt	313.42°C (rough estimate)
Dichte	1.0616 (rough estimate)
Brechungsindex	1.4970 (estimate)
storage temp.	2-8°C
Löslichkeit	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Also soluble in Water at alkalinepH.
Aggregatzustand	Crystalline Powder
pka	3.35±0.20(Predicted)
Farbe	White to faintly beige
BRN	1384051
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI	InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)
InChIKey	GLEVLJDDWXEYCO-UHFFFAOYSA-N
SMILES	C1(C)(C(O)=O)OC2=C(C)C(C)=C(O)C(C)=C2CC1
CAS Datenbank	53188-07-1(CAS DataBase Reference)
EPA chemische Informationen	3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid (53188-07-1)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	2
RTECS-Nr.	DJ2273000
HS Code	29339900

Gefahreninformationscode (GHS)

Trolox Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Trolox (53188-07-1) is a water soluble derivative of vitamin E. Displays antioxidant and radical scavenging activities.1 Prevents lipid peroxidation induced by CYP2E1 in Hep G2 cells.2 Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.3
Chemische Eigenschaften
white to fainly beige crystalline powder
Verwenden
Trolox is a Vitamin E analog that also maintains the antioxidant capabilities which Vitamin E shows. Neuroprotective product.
Verwenden
An antioxidant derived from water-soluble vitamin E
Definition
ChEBI: A chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capa ity of complex mixtures.
Application
Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. lt is commonly used as a standard or positive control in antioxidant assays. In addition, trolox is used to assessthe role of oxidative injury in processes like neuronal cell death and aging. It is effective as adjunctivetherapy in the treatment of certain cancers.
Allgemeine Beschreibung
(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox) exhibits radical scavenging and antioxidant activities.
Mechanism of action
Trolox can protect against oxidative stress, genotoxicity and inflammation induced by CS through ROS scavenging mechanism, and serve as a potential antioxidant prevention strategy against oxidative injury of ATII cells in CS-related lung diseases.
Lager
Store at +4°C
Einzelnachweise
1) Massey et al. (1990), Free radical damage in neonatal rat cardiac myocyte cultures: effects of alpha-tocopherol, Trolox and phytol; Free Radic. Biol. Med., 8 449 2) Chen et al. (1998), Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells; Mol. Pharmacol., 53 638 3) Brookes et al. (1996), Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes; Arch. Biochem. Biophys., 333 482

Trolox Upstream-Materialien And Downstream Produkte

6-Hydroxy-2,5,7,8-tetramethylchroman-2-carbonsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

53188-07-1, Trolox Verwandte Suche:

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