Semagacestat

Bezeichnung:Semagacestat

CAS-Nr425386-60-3

Englisch Name:Semagacestat

CBNumberCB71511579

SummenformelC19H27N3O4

Molgewicht361.44

MOL-Datei425386-60-3.mol

Semagacestat physikalisch-chemischer Eigenschaften

Schmelzpunkt	208-212 °C
Siedepunkt	681.9±55.0 °C(Predicted)
Dichte	1.22
Flammpunkt	366.2℃
storage temp.	2-8°C
Löslichkeit	DMSO (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	12.97±0.20(Predicted)
Farbe	White

Sicherheit

HS Code

29337900

Gefahreninformationscode (GHS)

Semagacestat Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White Solid
Verwenden
Semagacestat is an inhibitor of the γ-secretase enzyme. γ-Secretase enzyme is pivotal in the generation of β-amyloid (Aβ), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer''s disease (AD).
Definition
ChEBI: (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide is a peptide.
Biologische Aktivität
semagacestat (also known as ly450139), [(2s)-2-hydroxy-n-((2s)-1-((1s)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1h-benzo[d]azepin-1ylamino)-1-oxopropan-2-yl)-3-methylbutanamide] is an azepine class γ-secretase, which is currently being investigated as a potential disease-modifying agent for the treatment of alzheimer’s disease (ad). it reduces the rate of formation of amyloid-β (aβ), a major component of the neuritic plaque in the brains of ad patients, in human subjects and animal models including mice, beagle dogs and guinea pigs. according to previous studies, semagacestat slows the accumulation of aβ in the brains of transgenic mice overexpressing mutant human amyloid precursor protein v717f (pdapp mice) and exhibits a dose-dependent decrease of plasma in ad patients.ping yi, chad hadden, palaniappan kulanthaivel, nathan calvert, william annes, thomas brown, robert j. barbuch, archana chaudhary, mosun a. ayan-oshodi, and barbara j. ring. disposition and metabolism of semagacestat, a γ-secretase inhibitor, in humans. drug metabolism and disposition 2010; 38(4): 554-565
target
Aβ42
Lager
Store at -20°C

Semagacestat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

425386-60-3, Semagacestat Verwandte Suche:

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