6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  6-Chloro-3-hydroxypyridazine-4-carboxylic acid

• Synthese

  

  286946-24-5

  

  50681-26-0

  A. Methyl 3,6-dichloropyridazine-4-carboxylate (2.00 g, 10.4 mmol) was dissolved in dioxane (9.0 mL) and 1M hydrochloric acid solution (10.4 mL) was added. The reaction mixture was stirred at 90°C for 20 hours. After completion of the reaction, the mixture was cooled to 0 °C and the precipitate was collected by filtration. The precipitate was washed with cold water followed by a small amount of pyridazine acid Z.1 to afford the target product 3-oxo-6-chloro-2,3-dihydropyridazine-4-carboxylic acid (955 mg, 53% yield). The product was confirmed by HPLC-MS analysis (MS (MH)+ = 173; retention time t Ret = 0.00min; analytical method: LCMSBAS1).

• Einzelnachweise

  [1] Patent: WO2011/131741, 2011, A1. Location in patent: Page/Page column 62-63
  [2] Patent: WO2011/144622, 2011, A1. Location in patent: Page/Page column 55
  [3] Patent: US2012/94976, 2012, A1. Location in patent: Page/Page column 33-34

6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid Upstream-Materialien And Downstream Produkte

6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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