Interferon alfa-2b
Bezeichnung:Interferon alfa-2b
CAS-Nr98530-12-2
Englisch Name:Interferon alfa-2b
CBNumberCB71475147
SummenformelC16H17Cl3I2N3NaO5S
Molgewicht746.54599
MOL-Datei98530-12-2.mol
Gefahreninformationscode (GHS)
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Bildanzeige (GHS)
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Alarmwort
Warnung
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Gefahrenhinweise
H315:Verursacht Hautreizungen.
H373:Kann die Organe schädigen bei längerer oder wiederholter Exposition.
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Sicherheit
P260:Dampf/Aerosol/Nebel nicht einatmen.
P264:Nach Gebrauch gründlich waschen.
P264:Nach Gebrauch gründlich waschen.
P280:Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352:BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P314:Bei Unwohlsein ärztlichen Rat einholen / ärztliche Hilfe hinzuziehen.
P321:Besondere Behandlung
P332+P313:Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P362:Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.
P501:Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.
Interferon alfa-2b Chemische Eigenschaften,Einsatz,Produktion Methoden
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Verwenden
Antineoplastic; biological response modifier. -
Indications
Interferon alfa-2b (Intron A) is a recombinant DNA product derived from the interferon alfa-2b gene of human white blood cells. Its mechanism of antitumor action involves binding to a plasma membrane receptor but is otherwise poorly understood. Its serum half-life is 2 to 3 hours after parenteral administration. -
Trademarks
Intron A (Schering); Intron A HSA-free (Schering). -
Allgemeine Beschreibung
Interferon alfa-2b, Intron A, a water-soluble protein of165 amino acids and an approximate molecular mass of19,200 Da, is expressed from a recombinant strain of E. coli.This interferon molecule possesses an arginine at position23 and a histidine at position 34.Interferon alfa-2b is a broad-spectrum agent. It is indicatedfor hairy cell leukemia, condyloma acuminata (genital or venereal warts), AIDS-related Kaposi sarcoma, and chronichepatitis B and C infections.Intron A can be administered by the SC, IM, or IV routes,by infusion or by intralesional routes. The dose is 1 to 35 millionIU/day, depending on the application. The drug is suppliedas a solution or as a powder for solution, and both formscontain albumin, glycine, and sodium phosphate buffer.Hence, they should not be shaken. Vials of solution should bestored at 2°C to 8°C without freezing. The powder is stablefor 18 months at room temperature or 7 days at 45°C. -
Clinical Use
Interferon alfa-2b is useful in the treatment of a rare form of chronic leukemia, hairy cell leukemia, in which it produces remissions in 60 to 80% of patients. However, it has minimal antitumor activity in most human cancers.Remissions lasting a few months have been observed in 10 to 20% of patients with lymphomas, multiple myeloma, melanoma, renal cell carcinoma, and ovarian carcinoma. -
Nebenwirkungen
The adverse effects of interferon alfa-2b include fever and a flulike syndrome of muscle ache, fatigue, headache, anorexia, and nausea. Other less common side effects include leukopenia, diarrhea, dizziness, and skin rash. -
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Aminophylline and theophylline: metabolism of aminophylline and theophylline reduced, consider reducing dose of aminophylline and theophylline
. Antivirals: increased risk of peripheral neuropathy with telbivudine
. Immunosuppressants, e.g. ciclosporin, tacrolimus, sirolimus may have an antagonistic effect.
Administration of interferon in combination with other chemotherapeutic agents, e.g. cytarabine, cyclophosphamide, doxorubicin may lead to increased risk of severe toxicity. -
Stoffwechsel
Alpha-interferons are totally filtered through the glomeruli and undergo rapid proteolytic degradation during tubular reabsorption, rendering a negligible reappearance of intact alfa interferon in the systemic circulation.
Interferon alfa-2b Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global(8)Suppliers
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Henan Fengda Chemical Co., Ltd
Telefon +86-371-86557731<br/>+86-13613820652
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Beijing HuaMeiHuLiBiological Chemical
Telefon 010-56205725
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Nanjing Shizhou Biology Technology Co.,Ltd
Telefon 13675144456
E-Mail sean.lv@synzest.com
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Hubei Shishun Biotechnology Co. Ltd
Telefon 027-59223025<br/>15107168801
E-Mail 1718480011@qq.com
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Shaanxi Dideu Medichem Co. Ltd
Telefon 029-81124267<br/>15229202216
E-Mail 1073@dideu.com
98530-12-2, Interferon alfa-2b Verwandte Suche:
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