ChemicalBook Produktkatalog Analytische Chemie Standard Pharmazeutische Referenzstandards und Verunreinigungsreferenzstandards endo-(±)-8-Aza-8-isopropylbicyclo[3.2.1]oct-3-yl-(hydroxymethyl)phenylacetat

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Struktur

endo-(±)-8-Aza-8-isopropylbicyclo[3.2.1]oct-3-yl-(hydroxymethyl)phenylacetat

Bezeichnung:endo-(±)-8-Aza-8-isopropylbicyclo[3.2.1]oct-3-yl-(hydroxymethyl)phenylacetat

CAS-Nr22235-81-0

Englisch Name:endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

CBNumberCB6932642

SummenformelC19H27NO3

Molgewicht317.42258

MOL-Datei22235-81-0.mol

Synonyma

endo-(±)-8-Aza-8-isopropylbicyclo[3.2.1]oct-3-yl-(hydroxymethyl)phenylacetat

endo-(±)-8-Aza-8-isopropylbicyclo[3.2.1]oct-3-yl-(hydroxymethyl)phenylacetat physikalisch-chemischer Eigenschaften

Schmelzpunkt	112-114°C
Siedepunkt	448.8±45.0 °C(Predicted)
Dichte	1.15±0.1 g/cm3(Predicted)
storage temp.	Refrigerator
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	14.12±0.10(Predicted)
Farbe	White to Pale Orange

Gefahreninformationscode (GHS)

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Off-White to Pale Orange Solid
Verwenden
N-Isopropyl Noratropine is a Noratropine derivative, an intermediate in the production of Ipratropium.
Biologische Aktivität
n-isopropylnoratropine is a noratropine derivative and an intermediate in the production of ipratropium, an atropine-like bronchodilator drug via an anticholinergic pathway. n-isopropylnoratropine is used to examine the stability of ipratropium [1].muscarinic acetylcholine receptors are acetylcholine receptors that form g protein-receptor complexes in the cell membranes of certain neurons and other cells.n-isopropylnoratropine is an intermediate in the production of ipratropium and used to examine the stability of ipratropium. ipratropium exhibits broncholytic action by reducing the influence of cholinergic on the bronchial musculature. ipratropium blocks muscarinic acetylcholine receptors and therefore promotes the degradation of cgmp. ipratropium bromide (ib) is an anticholinergic bronchodilatory agent to treat chronic obstructive pulmonary disease. in anesthetized dogs, ipratropium with 0.01 and 0.1 mg/ml constricted the airways to 22 +/- 2% and 20 +/- 3% of control, respectively, whereas larger concentrations caused bronchodilation [2]. in moderate asthmatic patients, ipratropium bromide (ib) induced a significant shift of dose-response curve to inhalation of substance p (sp), suggesting that bronchoconstriction induced by sp could be attributed to a weak cholinergic activation [3].
Einzelnachweise
[1]. kasawar gb, farooqui m. development and validation of a stability indicating rp-hplc method for the simultaneous determination of related substances of albuterol sulfate and ipratropium bromide in nasal solution. j pharm biomed anal. 2010 may 1;52(1):19-29.
[2]. groeben h, brown rh. ipratropium decreases airway size in dogs by preferential m2 muscarinic receptor blockade in vivo. anesthesiology. 1996 oct;85(4):867-73.
[3]. crimi n, palermo f, oliveri r, et al. influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance p. ann allergy. 1990 aug;65(2):115-20.

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Upstream-Materialien And Downstream Produkte

endo-(±)-8-Aza-8-isopropylbicyclo[3.2.1]oct-3-yl-(hydroxymethyl)phenylacetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

22235-81-0, endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate Verwandte Suche:

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