7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion

Bezeichnung:7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion

CAS-Nr14110-64-6

Englisch Name:CYTOCHALASIN A

CBNumberCB6735221

SummenformelC29H35NO5

Molgewicht477.59

MOL-Datei14110-64-6.mol

Synonyma

7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion

7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion

7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion physikalisch-chemischer Eigenschaften

Schmelzpunkt	190-191 °C
Siedepunkt	725.1±60.0 °C(Predicted)
Dichte	1.20±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	ethanol: 20 mg/mL, clear, colorless
pka	13.54±0.70(Predicted)
Aggregatzustand	Powder
Farbe	White
Wasserlöslichkeit	Soluble in DMF, DMSO, ethanol and acetone. Insoluble in water.
Sensitive	Light Sensitive
BRN	949521
LogP	1.849 (est)
EPA chemische Informationen	Cytochalasin A (14110-64-6)

Sicherheit

Kennzeichnung gefährlicher	T+,T
R-Sätze:	26/27/28-63
S-Sätze:	28-36/37-45
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
F	10
HazardClass	6.1(a)
PackingGroup	I
HS Code	29349990

Gefahreninformationscode (GHS)

CYTOCHALASIN A Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC₅₀ = 3 μM). Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (K_i = 4.0 and 0.6 μM, respectively). Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.
Chemische Eigenschaften
white powder
Verwenden
Cytochalasin A binds to the glucose transporter and inhibit monosaccharide transport across the plasma membrane. Preventing growth and sugar uptake in a Saccharomyces strain.
Verwenden
Cytochalasin A is one of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced morphogenic activity in animals and plants. Like most cytochalsins, cytochalasin A exhibits potent inhibition of actin filament function leading to cell death by apoptosis, and displays a broad range of resultant cellular actions. Despite the common mode of action, there is evidence that individual members of the class display diverse selectivity. Specifically, cytochalasin A is one of the few cytochalasins exhibiting activity against HIV-1 protease.
Definition
ChEBI: Cytochalasin A is a cytochalasin.
Biochem/physiol Actions
Cytochalasin A reacts with sulfhydryls, and inhibits growth and glucose transport in Saccharomyces. Cytochalasin A is an oxidizing analog of cytochalsin B.

CYTOCHALASIN A Upstream-Materialien And Downstream Produkte

7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

14110-64-6, CYTOCHALASIN A Verwandte Suche:

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