CYTOCHALASIN E Struktur

21,23-Dioxa(13)cytochalasa-13,19-dien-1,17,22-trion, 6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E)-

Bezeichnung:21,23-Dioxa(13)cytochalasa-13,19-dien-1,17,22-trion, 6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E)-

CAS-Nr36011-19-5

Englisch Name:CYTOCHALASIN E

CBNumberCB5192252

SummenformelC28H33NO7

Molgewicht495.56

MOL-Datei36011-19-5.mol

Synonyma

21,23-Dioxa[13]cytochalasa-13,19-dien-1,17,22-trion, 6,7-Epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E)-

21,23-Dioxa(13)cytochalasa-13,19-dien-1,17,22-trion, 6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E)-

21,23-Dioxa(13)cytochalasa-13,19-dien-1,17,22-trion, 6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E)- physikalisch-chemischer Eigenschaften

Schmelzpunkt	206 °C
Siedepunkt	587.59°C (rough estimate)
Dichte	1.2415 (rough estimate)
Brechungsindex	1.6290 (estimate)
storage temp.	-20°C
Löslichkeit	DMF: 11 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml
Aggregatzustand	White solid.
pka	11.22±0.70(Predicted)
Farbe	White to off-white
BRN	1096975
LogP	1.920 (est)

Sicherheit

Kennzeichnung gefährlicher	T+,T
R-Sätze:	26/27/28-63
S-Sätze:	28-36/37-45
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
RTECS-Nr.	HA5360000
F	10
HazardClass	6.1(a)
PackingGroup	I
HS Code	29349990
Giftige Stoffe Daten	36011-19-5(Hazardous Substances Data)

Gefahreninformationscode (GHS)

CYTOCHALASIN E Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin E is an epoxide-containing analog of cytochalasin B which potently and selectively inhibits the growth of endothelial cells (IC₅₀ < 1 nM), impairing angiogenesis and tumor growth. This cytochalasin does not inhibit glucose transport or HIV-1 protease activity.
Chemische Eigenschaften
white powder
Verwenden
Cytochalasin E has been used as:
- a toxin to study its effects on avocado plants
- a component of the incubating medium in feline junctional adhesion molecule 1 (fJAM-1) expression assay
- an inhibitor of actin polymerization to study its effects on mitochondria uptake by mice endothelial cells
Verwenden
Cytochalasin E is a fungal metabolite which has been shown to exhibit antimicrobial and antibacterial effects. Cytochalasin E is a microfilament inhibitor enhancing the low-affinity Fc epsilon receptor (CD23) expression.
Verwenden
Cytochalasin E is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. Despite the common mode of action, there is evidence that individual members display diverse selectivity. Specifically, cytochalasin E acts as an angiogenesis inhibitor and, unlike other cytochalasins, does not inhibit glucose transport.
Definition
ChEBI: A natural product found in Arthrinium sacchari.
Biochem/physiol Actions
Cytochalasin E is an epoxide that exhibits anti-proliferative activity in endothelial cells in vitro. It also participates in inhibiting tumor growth and angiogenesis in vivo. Cytochalasin E also possesses antimicrobial and antiviral properties.

21,23-Dioxa(13)cytochalasa-13,19-dien-1,17,22-trion, 6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

36011-19-5, CYTOCHALASIN E Verwandte Suche:

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