2-Bromo-4-methoxyphenol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2-Bromo-4-methoxyphenol Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  3-Bromo-4-methoxyphenol is a malate dehyrogenase inhibitor.

• Synthese

  

  124764-37-0

  

  17332-12-6

  General procedure for the synthesis of 3-bromo-4-methoxyphenol from 3-bromo-4-methoxyphenyl acetate: a solution of potassium hydroxide (290 mg, 5.19 mmol) in water (2.5 mL) was added to a solution of 3-bromo-4-methoxyphenyl acetate (1.2 g, 4.9 mmol) in methanol (18.5 mL). The reaction mixture was stirred at room temperature for 30 min, followed by removal of the solvent under reduced pressure. Water (40 mL) was added to the residue and 1.2 M aqueous hydrochloric acid (4.3 mL) was added dropwise until the mixture was acidic. The mixture was extracted with dichloromethane (2 x 40 mL), the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the filtrate was evaporated under reduced pressure to give 3-bromo-4-methoxyphenol (976 mg, 98% yield) as a light yellow solid.LCMS analysis (Method A): retention time (RT) = 2.11 min; no ionization was observed.TLC analysis: Rf = 0.28 (unfolding reagent ratio 1:4 ethyl acetate:hexane).

• Einzelnachweise

  [1] Patent: WO2009/109743, 2009, A1. Location in patent: Page/Page column 37; 38
  [2] Patent: CN105001107, 2016, B. Location in patent: Paragraph 0045; 0047
  [3] Patent: WO2004/16621, 2004, A1. Location in patent: Page 31

2-Bromo-4-methoxyphenol Upstream-Materialien And Downstream Produkte

2-Bromo-4-methoxyphenol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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