25 MG CALPAIN INHIBITOR IIRESEARCH GRADE

Bezeichnung:25 MG CALPAIN INHIBITOR IIRESEARCH GRADE

CAS-Nr136632-32-1

Englisch Name:25 MG CALPAIN INHIBITOR IIRESEARCH GRADE

CBNumberCB6500395

SummenformelC19H35N3O4S1

Molgewicht401.56

MOL-DateiMol file

25 MG CALPAIN INHIBITOR IIRESEARCH GRADE physikalisch-chemischer Eigenschaften

storage temp.	−20°C
Löslichkeit	Soluble in ethanol at 20mg/ml
Aggregatzustand	powder
Farbe	white
BRN	7693643
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
F	3-10

25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki?= 120 nM, calpain II, Ki?= 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1?Weak inhibitor of the chymotrypsin-like activity of the proteasome.2?Cell permeable.
Verwenden
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.
Verwenden
ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II?in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.
Definition
ChEBI: (2S)-2-acetamido-4-methyl-N-[4-methyl-1-[[4-(methylthio)-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]pentanamide is a peptide.
Einzelnachweise
1) Sasaki?et al.?(1990),?Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins;?J. Enzyme Inhib.,?3?195 2) Vinitsky?et al.?(1992),?Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry,?31?9421

25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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