Mizoribine

Bezeichnung:Mizoribine

CAS-Nr50924-49-7

Englisch Name:Mizoribine

CBNumberCB6426440

SummenformelC9H13N3O6

Molgewicht259.22

MOL-Datei50924-49-7.mol

Mizoribine physikalisch-chemischer Eigenschaften

Schmelzpunkt	>2000C
alpha	D27 -35° (c = 0.8 in H2O)
Siedepunkt	402.47°C (rough estimate)
Dichte	1.4155 (rough estimate)
Brechungsindex	1.5100 (estimate)
storage temp.	2-8°C
Löslichkeit	DMSO (Slightly), Water (Slightly)
Aggregatzustand	Solid
pka	6.75(at 25℃)
Farbe	White to Off-White
maximale Wellenlänge (λmax)	280nm(lit.)
Merck	14,6222
InChIKey	HZQDCMWJEBCWBR-UUOKFMHZSA-N
CAS Datenbank	50924-49-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	46-60-61-36/37/38
S-Sätze:	53-22-26-36/37/39-45
WGK Germany	3
RTECS-Nr.	NI3980000
HS Code	29349990
Toxizität	LD50 in mice (g/kg): >1.5 i.v., >2.4 i.p. (Mizuno, 1975)

Gefahreninformationscode (GHS)

Mizoribine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R46:Kann vererbbare Schäden verursachen.
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R61:Kann das Kind im Mutterleib schädigen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Mizoribine is an orally active immunosuppressant isolated from Eupenicillium brefeldianum. It is reported to inhibit both cell-mediated and antibody mediated immune responses. Mizoribine is approved for use in the prevention of rejection of kidney transplants.
Beschreibung
Mizoribine is an imidazole nucleoside with immunosuppressive properties. It inhibits T cell proliferation in response to various mitogenic stimuli by 10-100% when used at concentrations ranging from 1 to 50 μg/mL. Mizoribine inhibits proliferation of stimulated T cells (IC₅₀ = 5 μg/ml), which can be reversed by guanosine. It also inhibits guanine nucleotide formation in T cells, reducing GTP pools by 40-60% when used at a concentration of 5 μg/ml. Mizoribine inhibits replication of hepatitis C virus (HCV) RNA in vitro (IC₅₀ = 100 μM). It suppresses glomerulosclerosis, urinary albumin excretion, interstitial fibrotic lesions, and macrophage infiltration into glomeruli and the interstitium in a rat model of type 2 diabetes when used at doses of 5 or 10 mg/kg. Mizoribine also reduces MCP-1, osteopontin (OPN), and TGF-β1 mRNA expression in the kidney in the same model. Formulations containing mizoribine have been used for the prevention of rejection after renal transplantation as well as in the treatment of lupus nephritis, rheumatoid arthritis, and primary nephritic syndrome.
Chemische Eigenschaften
Crystalline Solid
Originator
Toyo Jozo (Japan)
Verwenden
Mizoribine has been used in topical treatment to evaluate its effect on ocular surface damage of dry eye in B6 mice subjected to desiccating stress (DS). It has also been used as an inosine monophosphate dehydrogenase (IMPDH) inhibitor to test its in vivo efficacy.
Verwenden
Nucleoside antibiotic with cytotoxic and immunosuppressive activity
Definition
ChEBI: Mizoribine is a member of imidazoles. It has a role as an anticoronaviral agent.
Trademarks
BREDININ
Biochem/physiol Actions
Mizoribine is an imidazole nucleoside possessing strong immunosuppressive properties. It selectively blocks T-cell proliferation response to mitogenic and allo-antigenic stimulation. Mizoribine blocks the movement of T cells from G to S phase. In addition, it significantly decreases the number of B cells at the S, G, and M phases. Mizoribine inhibits de novo synthesis of nucleotides by inhibition of inosine monophosphate dehydrogenase. The resulting nucleotide depletion inhibits DNA synthesis.(3)

Mizoribine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

50924-49-7, Mizoribine Verwandte Suche:

Send Inquriy