L-Penicillamine Struktur

L-(+)-β-Mercaptovalin

Bezeichnung:L-(+)-β-Mercaptovalin

CAS-Nr1113-41-3

Englisch Name:L-Penicillamine

CBNumberCB6302922

SummenformelC5H11NO2S

Molgewicht149.21

MOL-Datei1113-41-3.mol

Synonyma

L-(+)-β-Mercaptovalin

L-(+)-β-Mercaptovalin physikalisch-chemischer Eigenschaften

Schmelzpunkt	206 °C (dec.)(lit.)
Siedepunkt	251.8±35.0 °C(Predicted)
alpha	61.9 º (C=0.5 IN 1 M NAOH)
Dichte	1.113 (estimate)
Brechungsindex	63 ° (C=1, 1mol/L NaOH)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	Aqueous Base (Sparingly), DMSO (Slightly, Heated), Water (Slightly)
pka	2.13±0.12(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	White to almost white
Optische Aktivität	[α]24/D +61.9°, c = 0.5 in 1 M NaOH
Merck	14,7088
BRN	1722374
Stabilität	Hygroscopic
InChIKey	VVNCNSJFMMFHPL-GSVOUGTGSA-N
CAS Datenbank	1113-41-3(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-40-20/21/22
S-Sätze:	26-36-22-24/25
WGK Germany	2
RTECS-Nr.	YV9445500
HS Code	29309090
Toxizität	LD50 i.p. in rats: 350 mg/kg (Jaffe)

Gefahreninformationscode (GHS)

L-Penicillamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
white to almost white crystalline powder
Verwenden
Metal-chelating agent
Verwenden
As a Penicillin metabolite, L-Penicillamine can be used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.
Verwenden
L-Penicillamine is a metabolite of penicillin. L-Penicillamine is used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.
Indications
Penicillamine (Cuprimine) can be used to treat acute, severe rheumatoid arthritis, producing reductions in joint pain, edema, and stiffness.The response to penicillamine is usually delayed (4–12 weeks), and remissions can last several months after withdrawal of treatment. Radiographic evidence of this drug’s efficacy is limited; thus, penicillamine is seldom used to treat rheumatoid arthritis.
Definition
ChEBI: The L-enantiomer of penicillamine.
Mechanism of action
The mechanism of action of penicillamine is unknown, but some evidence suggests that it may involve the inhibition of angiogenesis, synovial fibroblast proliferation, or transcriptional activation. Because penicillamine can chelate copper and promote its excretion, it is used to treat Wilson’s disease (hepatolenticular degeneration) and has also been used in mercury and lead intoxication.
Pharmakologie
Penicillamine is readily absorbed from the GI tract and is rapidly excreted in the urine, largely as the intact molecule. Gradually increasing its dose minimizes side effects, which necessitate discontinuance of penicillamine therapy in perhaps one-third of patients. The most common side effects are maculopapular pruritic dermatitis, GI upset, loss of taste sensation, mild to occasionally severe thrombocytopenia and leukopenia,and mild proteinuria, which at times may progress to the nephritic syndrome. Discontinuance of therapy usually results in a rapid disappearance of side effects.
Sicherheitsprofil
A poison by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx and SOx.
läuterung methode
Same as preceding entry for its enantiomer. [Beilstein 4 IV 3228.]

L-Penicillamine Upstream-Materialien And Downstream Produkte

L-(+)-β-Mercaptovalin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1113-41-3, L-Penicillamine Verwandte Suche:

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