cis-4-[Phosphonomethyl]-piperidine-2-carboxylic acid

cis-4-[Phosphonomethyl]-piperidine-2-carboxylic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  CGS 19755 is a potent and competitive NMDA antagonist.

• Definition

  ChEBI: Selfotel is a non-proteinogenic alpha-amino acid.

• Biologische Aktivität

  Potent, competitive NMDA receptor antagonist. Anticonvulsant and neuroprotective. Also available as part of the Mixed NMDA Receptor Tocriset™ .

• in vivo

  Selfotel (CGS 19755) administered p.o. by gavage has little or no effect in these test procedures. In an experimental model of anxiety in rats^[1].
  Selfotel (CGS 19755) significantly increases conflict responding within a relatively narrow dose range (minimum effective dose, 1.73 mg/kg i.p.)^[1].
  Selfotel (CGS 19755) blocks the harmaline-induced increase in cerebellar cyclic GMP levels at a dose of 4 mg/kg i.p. with duration of action exceeding 2 hr^[2].
  Selfotel (CGS 19755) inhibits convulsions elicited by maximal electroshock in rat (ED₅₀ = 3.8 mg/kg i.p. 1 hr after administration) and in mouse (ED₅₀ = 2.0 mg/kg i.p. 0.5 hr after administration)^[2].
  

• Lager

  Store at RT

cis-4-[Phosphonomethyl]-piperidine-2-carboxylic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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