Trimethylamin, N-oxid

Bezeichnung:Trimethylamin, N-oxid

CAS-Nr1184-78-7

Englisch Name:Trimethylamine N-oxide

CBNumberCB6140124

SummenformelC3H9NO

Molgewicht75.11

MOL-Datei1184-78-7.mol

Synonyma

Trimethylamin, N-oxid

Trimethylamin, N-oxid physikalisch-chemischer Eigenschaften

Schmelzpunkt	220-222 °C (lit.)
Siedepunkt	133.8°C (rough estimate)
Dichte	0.9301 (rough estimate)
Dampfdruck	23.5Pa at 20℃
FEMA	4245 \| TRIMETHYLAMINE OXIDE
Brechungsindex	1.4698 (estimate)
storage temp.	Hygroscopic, Room Temperature, under inert atmosphere
Löslichkeit	Chloroform, DMSO, Methanol (Slightly)
pka	4.65(at 25℃)
Aggregatzustand	Solid
Farbe	Pale Yellow
Geruch (Odor)	odorless
Wasserlöslichkeit	793g/L at 24.5℃
Merck	14,9711
JECFA Number	1614
Stabilität	Hygroscopic
InChI	1S/C3H9NO/c1-4(2,3)5/h1-3H3
InChIKey	UYPYRKYUKCHHIB-UHFFFAOYSA-N
SMILES	C[N+](C)(C)[O-]
LogP	-2.79
EPA chemische Informationen	Methanamine, N,N-dimethyl-, N-oxide (1184-78-7)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39
WGK Germany	3
TSCA	TSCA listed
HS Code	2904.20.5000
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Inhalation Acute Tox. 4 Oral

Gefahreninformationscode (GHS)

Trimethylamine N-oxide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Trimethylamine N-oxide (TMAO) is a metabolite of choline, phosphatidylcholine, and L-carnitine . It is formed by gut microbiota-mediated metabolism of choline, phosphatidylcholine, and L-carnitine to TMA followed by oxidation of TMA by flavin-containing monooxygenase 3 (FMO3) in the liver. Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-prone ApoE^-/- mice. Plasma levels of TMAO are elevated in patients with chronic kidney disease and decreased in patients with active, compared with inactive, ulcerative colitis. Elevated plasma levels of TMAO are associated with increased risk of cardiovascular disease.
Chemische Eigenschaften
White crystalline powder
Chemische Eigenschaften
Colorless to yellow solid; odorless.
Verwenden
TrimethylamineN-oxide can be used:
- As a demetallationand decarbonylationreagent for organometallic compounds.
- To prepare azomethine ylide by reaction with lithium di-isopropylamide. This, in turn, may be reacted with simple alkenes to obtain corresponding pyrrolidines.
- To mediate the conversion of thiols to disulfides.
Definition
ChEBI: An N-oxide derived from triethylamine.
Allgemeine Beschreibung
TrimethylamineN-oxide is an organic compound that belongs to the class of amine oxides. It is generally found in the tissues of marine organisms, wherein it helps protect them from harsh conditions like salinity, hydrostatic pressure, temperature, and high urea.
Flammability and Explosibility
Not classified
reaction suitability
reagent type: oxidant

Trimethylamine N-oxide Upstream-Materialien And Downstream Produkte

Trimethylamin, N-oxid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1184-78-7, Trimethylamine N-oxide Verwandte Suche:

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