Irinotecan hydrochloride trihydrate

Bezeichnung:Irinotecan hydrochloride trihydrate

CAS-Nr136572-09-3

Englisch Name:Irinotecan hydrochloride trihydrate

CBNumberCB6122430

SummenformelC33H45ClN4O9

Molgewicht677.18

MOL-Datei136572-09-3.mol

Irinotecan hydrochloride trihydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	250-256°C (dec.)
Siedepunkt	257°C(lit.)
storage temp.	2-8°C
Löslichkeit	Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).
Aggregatzustand	White solid.
Farbe	Yellow
Wasserlöslichkeit	Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
Merck	14,5091
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.
CAS Datenbank	136572-09-3(CAS DataBase Reference)

Sicherheit

R-Sätze:	22
S-Sätze:	20/21-22
RTECS-Nr.	DW1060750
HS Code	29349990
Toxizität	dog,LD50,intravenous,40mg/kg (40mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.

Gefahreninformationscode (GHS)

Irinotecan hydrochloride trihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3
Chemische Eigenschaften
White powder
Verwenden
Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor.
Definition
ChEBI: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
Trademarks
Camptosar (Pharmacia &Upjohn) .
Hazard
Moderately toxic by ingestion.
Einzelnachweise
1) Kunimoto et al. (1987) Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin against murine tumors; Cancer Res., 47 5944 2) Mathijssen et al., (2002) Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan; Curr. Cancer Drug Targets, 253 5892 3) Pfizer drug insert

Irinotecan hydrochloride trihydrate Upstream-Materialien And Downstream Produkte

Irinotecan hydrochloride trihydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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