Oxandrolon Produkt Beschreibung

Oxandrolone Struktur
53-39-4
  • CAS-Nr.53-39-4
  • Bezeichnung:Oxandrolon
  • Englisch Name:Oxandrolone
  • Synonyma:Oxandrolon
    8075cb;Anavar;sc11585;Lonavar;Vasorome;SC 11585;Provitar;Protivar;8075c.b.;Oxandren
  • CBNumber:CB6112482
  • Summenformel:C19H30O3
  • Molgewicht:306.44
  • MOL-Datei:53-39-4.mol
Oxandrolon physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :235-238°C
  • alpha  :D25 -23° (c = approx 1% in chloroform)
  • Siedepunkt: :387.04°C (rough estimate)
  • Dichte :1.0829 (rough estimate)
  • Brechungsindex :1.4200 (estimate)
  • storage temp.  :2-8°C
  • Löslichkeit :DMSO: soluble2mg/mL (clear solution; warmed)
  • Aggregatzustand :powder
  • pka :15.15±0.60(Predicted)
  • Farbe :white to beige
  • Optische Aktivität :[α]/D -19 to -26°, c = 1 (CDCl3)
  • Merck  :6921
  • InChIKey :QSLJIVKCVHQPLV-PEMPUTJUSA-N
  • CAS Datenbank :53-39-4(CAS DataBase Reference)
  • NIST chemische Informationen :Oxandrolone(53-39-4)
Sicherheit

Oxandrolone Chemische Eigenschaften,Einsatz,Produktion Methoden

  • Beschreibung Oxandrolone is a synthetic anabolic-androgenic steroid. It is a 17 alpha-methylated version of dihydrotestosterone (DHT). It can be used for the treatment of many kinds of disorders such as idiopathic short stature, body mass loss due to catabolic illness, severe burns, trauma and hereditary angioedema as well as turner syndrome. Oxandrolone is especially effective in the treatment of severe burns without causing obvious side effects. It acts as an agonist of the androgen receptor, which modulates related gene expression to increase protein synthesis, further boosting muscle growth and increasing body mass as well as bone mineral density. However, it should be noted that its androgenic effect is less than its anabolic effect.
  • Chemische Eigenschaften White Solid
  • Originator Anavar,Searle,US,1964
  • Verwenden androgenic anabolic steroid;reverses catabolic tissue processes; promotes buildup of protein; increases erythropoietin production
  • Verwenden A synthetic, anabolic steroid. Used to promote muscle growth and combat involuntary weight loss. It has also been used to treat cases of osteoporosis.
  • Manufacturing Process To a solution of 6.36 parts of 17β-hydroxy-17α-methyl-5α-androst-1-en-3-one in 95 parts of acetic acid and 12 parts of water is added 40 parts of lead tetracetate and 0.6 part of osmium tetroxide. This mixture is stored at room temperature for about 24 hours, then is treated with 2 parts of lead tetracetate. Evaporation to dryness at reduced pressure affords a residue, which is extracted with benzene. The benzene extract is washed with water, and extracted with aqueous potassium bicarbonate. The aqueous extract is washed with ether, acidified with dilute sulfuric acid, then extracted with ethyl acetate-benzene. This organic extract is washed with water, dried over anhydrous sodium sulfate, and concentrated to dryness in vacuo. To a solution of the residual crude product in 20 parts of pyridine is added 10 parts of 20% aqueous sodium bisulfite and the mixture is stirred for about 20 minutes at room temperature
    This mixture is then diluted with water, washed with ethyl acetate, acidified with dilute sulfuric acid, and finally extracted with benzene. The benzene extract is washed with water, dried over anhydrous sodium sulfate, and evaporated to dryness at reduced pressure to produce crude 17β-hydroxy17α-methyl-1-oxo-1,2-seco-A-nor-5α-androstan-2-oic acid, which after recrystallization from aqueous isopropyl alcohol melts at about 166° to 173°C (decomposition).
    An aqueous slurry of 6 parts of 17β-hydroxy-17α-methyl-1-oxo-1,2-seco-Anor-5α-androstan-2-oic acid in 200 parts of water is made alkaline to pH 10 by the addition of dilute aqueous sodium hydroxide, then is treated with 6 parts of sodium borohydride. This mixture is allowed to react at room temperature for about 3 hours. Benzene is added and the resulting mixture is acidified carefully with dilute hydrochloric acid. The benzene layer is separated, and the aqueous layer is further extracted with benzene. The combined benzene extracts are washed successively with aqueous potassium bicarbonate and water, dried over anhydrous sodium sulfate, then evaporated to dryness in vacuo. The resulting residue is triturated with ether to afford pure 17β-hydroxy-17α-methyl-2-oxa-5α-androstan-3-one, MP about 235° to 238°C, according to US Patent 3,128,283.
  • Trademarks Oxandrin (Savient).
  • Therapeutic Function Androgen
  • Allgemeine Beschreibung Oxandrolone, 17β-hydroxy-17-methyl-2-oxaandrostan-3-one, is approved to aid in the promotionof weight gain after weight loss following surgery,chronic infections, or severe trauma and to offset protein catabolismassociated with long-term corticosteroid use.Oxandrolone is also used to relieve bone pain accompanyingosteoporosis. It has been used to treat alcoholic hepatitisand HIV wasting syndrome.
  • Biochem/physiol Actions Oxandrolone is a synthetic anabolic steroid. It is is a non-aromatizable androgen with no estrogenic effects and with mild androgenic activity. Clinical uses of oxandrolone include to promote weight gain after weight loss following extensive surgery or chronic infections or trauma, to offset the protein catabolism associated with prolonged administration of corticosteroids, to relieve bone pain frequently accompanying osteoporosis, and to treat Turner′s syndrome in girls.
  • Sicherheitsprofil Moderately toxic by ingestion andintraperitoneal routes. Experimental reproductive effects.When heated to decomposition it emits acrid smoke andfumes.
  • Chemical Synthesis Oxandrolone, 17β-hydroxy-17α-methyl-2-oxa-5-androstan-3-one (29.3.10), is made by oxidation of the C1–C2 double bond of 17β-hydroxy-17α-methyl-1-androsten- 3-one by a mixture of lead tetraacetate and osmium tetroxide with an opening of the A ring of the steroid system, which forms an aldehyde acid (29.3.9). Upon reducing the aldehyde group with sodium borohydride, intramolecular cyclization takes place, directly forming a lactone (29.3.10), which is the desired oxandrolone.

  • Einzelnachweise Li, H., et al. "The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis. " Burns Journal of the International Society for Burn Injuries 42.4(2016): 717.
    Hart, D. W., et al. "Anabolic effects of oxandrolone after severe burn." Annals of Surgery 233.4(2001): 556-564.
    Sheffieldmoore, M, et al. "Short-term oxandrolone administration stimulates net muscle protein synthesis in young men. " Journal of Clinical Endocrinology & Metabolism 84.8(1999): 2705-11.
    https://en.wikipedia.org/wiki/Oxandrolone
Oxandrolone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Oxandrolon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global(252)Suppliers
53-39-4, Oxandrolone Verwandte Suche:
  • ceticaciddelta-lactone
  • dodecahydro-3-hydroxy-6-(hydroxy-methyl)-3,3a,6-trimethyl-1h-benz[e]indene-7-a
  • Lonavar
  • NSC-67068
  • Protivar
  • Provitar
  • SC 11585
  • sc11585
  • Vasorome
  • 17BETA-HYDROXY-17-METHYL-2-OXA-5ALPHA-ANDROSTAN-3-ONE
  • 5-ALPHA-ANDROSTAN-2-OXA-17-ALPHA-METHYL-17 BETA-OL-3-ONE
  • 17beta-Hydroxy-17alpha-methyl-2-oxa-5alpha-androstan-3-one
  • OXANDROLONE
  • 17β-Hydroxy-17-methyl-2-oxa-5α-androst-3-one
  • (4aS,4bS,6aS,7R,9aS,9bR,11aS)-7-hydroxy-4a,6a,7-trimethyl-tetradecahydroindeno[4,5-h]isochromen-2(1H)-one
  • Oxandrolone CIII (50 mg)H0E2230.994mg/mg(ai)
  • Oxandrolone CIII (50 mg)
  • Oxandrolone 98%Min
  • Oxandrolone (CL)
  • Oxandrolone Tablet
  • 1-hydroxy-1,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,6,9,9b,10,11-dodecahydroindeno[4,5-h][2]benzopyran-7-one
  • 17-beta-hydroxy-17-methyl-2-oxa-5-alpha-androstan-3-on
  • 17beta-hydroxy-17-methyl-2-oxa-5alpha-androstan-3-on
  • 17-beta-hydroxy-17-methyl-2-oxa-androstan-3-one
  • 17-hydroxy-17-methyl-,(5-alpha,17-beta)-2-oxaandrostan-3-on
  • 17-hydroxy-17-methyl-,(5alpha,17beta)-2-oxaandrostan-3-on
  • 1H-Benz(e)indene-7-acetic acid, dodecahydro-3-hydroxy-6-(hydroxymethyl)-3,3a,6-trimethyl-, delta-lactone
  • 2-Oxa-5alpha-androstan-3-one, 17beta-hydroxy-17-methyl-
  • 2-Oxaandrostan-3-one, 17-hydroxy-17-methyl-, (5alpha,17beta)-
  • 7-Hydroxy-4a,6a,7-trimethyltetradecahydroindeno[4,5-H]isochromen-2(1H)-one
  • 8075 C. B.
  • 8075c.b.
  • 8075cb
  • Anavar
  • Oxandrolone (Anavar)
  • Oxandrolone 98%Min (Anavar)
  • Oxandrolone(Oxandrin)
  • Oral Anabolic Steroid Raw Powder 53-39-4 Anavar Oxanabol Oxandrolone MOQ 10gram/bag
  • Oxndrolone
  • 17β-Hydroxy-17α-methyl-2-oxa-5α-androstan-3-one
  • Oxandren
  • (4aS,4bS,6aS,7S,9aS,9bR,11aS)-7-hydroxy-4a,6a,7-triMethyltetradecahydroindeno[4,5-h]isochroMen-2(1H)-one
  • Cyclopenta[5,6]naphtho[1,2-c]pyran-2(1H)-one, tetradecahydro-7-hydroxy-4a,6a,7-trimethyl-, (4aS,4bS,6aS,7S,9aS,9bR,11aS)-
  • 17b-Hydroxy-17-methyl-2-oxa-5a-androstan-3-one
  • (1S,3aS,3bR,5aS,9aS,9bS,11aS)-1-hydroxy-1,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,6,9,9b,10,11-dodecahydroindeno[4,5-h]isochromen-7-one
  • Anavar/Anavar oxandrolone
  • (4BS,?7S,?9AS,?9BR,?11AS)-?TETRADECAHYDRO-?7-?HYDROXY-?4AS,?6AS,?7-?TRIMETHYL-?CYCLOPENTA[5,?6]NAPHT
  • Oxandrolone fandachem
  • oxandxolone
  • Oxandrolone USP/EP/BP
  • Oxandrolone (Anavar) (53-39-4)
  • Hydroxy methylene dragon
  • Hydrogen oxygen a dragon
  • 172-Hydroxy-17±-methyl-2-oxa-3-oxo-5±-androstan
  • 53-39-4
  • 53-93-4
  • Inhibitors
  • anavar