Morinamid

morinamide Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Morinamide,Bracco Industria Chimica S.p.A.

• Verwenden

  Morphazinamide is an anti-tuberculosis agent. Also, it is derived from Pyrazinamide (P840600), which is an anti-bacterial (tuberculostatic).

• Definition

  ChEBI: Morinamide is a member of pyrazines, a secondary carboxamide and a member of morpholines.

• Manufacturing Process

  98.5 parts by weight 2-pyrazinecarboxamide was mixed with 260 parts by volume of diethylamine. 91 parts by weight of 37% formaldehyde was added to above mixture by stirring for 30 minutes. The reaction mixture was spontaneously heated to 50°C. Then it heated to reflux for 5 hours on water bath. After that it was distilled to dryness at temperature between 40°-50°C. The residue was dissolved with about 200 parts by volume of ligroin (B.P. 60°C) by heating. The solution was filtered hot for removing the not reacted 2-pyrazinecarboxamide. Then it was cooled to -10°C and desired N- (diethylaminomethyl)-pyrazinecarboxylic acid amide discharged. It was filtered off and recrystallized from light petrol ester. Yield about 90%, MP: 47°-50°C.
  500 parts by weight of N-(diethylaminomethyl)pyrazinecarboxylic acid amide and 2500 parts by volume of was mixed and heated by stirring to temperature 140°-150°C. At 60°-100°C a distillation begun and ended at 127°C (a boiling point of morpholine). The distillate consisted from diethylamine and morpholine. After 30-60 minutes the mixture was cooled to 50°C and distilled in vacuum to dryness. The residue was recrystallized from 400 parts by volume of benzene to give N-(morpholinomethyl)pyrazinecarboxamide, yield 92%, MP: 114°-117°C.

• Therapeutic Function

  Antitubercular

morinamide Upstream-Materialien And Downstream Produkte

Morinamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(4)Suppliers

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