Propylhexedrin

propylhexedrine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Adrenergic (vasoconstrictor).

• Definition

  ChEBI: Propylhexedrine is a secondary amino compound.

• Trademarks

  Dristan Inhaler (Whitehall-Robins);Benzedrex;Chp-depot;Cyclexedrine;Eggobesin;Eventin.

• Weltgesundheitsorganisation (WHO)

  Propylhexedrine, a sympathomimetic amine, has been widely available since 1949 in over-the-counter inhalants for nasal decongestion and in oral anorexic preparations. As dependence can occur and because abuse has been reported, propylhexedrine was subjected in 1986 to control under Schedule IV of the 1971 Convention on Psychotropic Substances. (Reference: (WHTAC2) 2nd Report of the WHO Expert Committee on Drug Dependence (IV), 729, , 1985)

• Synthesis Reference(s)

  Journal of the American Chemical Society, 80, p. 5270, 1958 DOI: 10.1021/ja01552a063

• Allgemeine Beschreibung

  Propylhexedrine is another analog ofamphetamine in which the aromatic ring has been replacedwith a cyclohexane ring. This drug produces vasoconstrictionand a decongestant effect on the nasal membranes, butit has only about one half the pressor effect of amphetamineand produces decidedly fewer effects on the CNS. Its majoruse is for a local vasoconstrictive effect on nasal mucosa inthe symptomatic relief of nasal congestion caused by thecommon cold, allergic rhinitis, or sinusitis.

• Synthese

  Propylhexedrine is prepared by catalytic hydrogenation of (±)- or (-)-ephedrine in a strong mineral acid .