Iobenzaminsure

iobenzamic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Bilibyk,Byk Gulden

• Verwenden

  Diagnostic aid (radiopaque medium, cholecystographic).

• Definition

  ChEBI: Iobenzamic acid is an organic molecular entity.

• Manufacturing Process

  1013.2 g 3-amino-2,4,6-triiodobenzoyl chloride are dissolved in a minimum amount of hot dioxane and caused to flow into 700.6 g molten methyl β- anilinopropionate with stirring. After the ensuing exothermic reaction has gradually terminated the reaction mixture is heated on a steam bath for about 3 h and while boiling hot has then methanol and methanolic 3 N HCl added thereto, where after it is cooled. The precipitated solids are separated and washed with ether. 953.0 g methyl β-N-(3-amino-2,4,6-triiodobenzoyl)- phenylaminopropionate are obtained having a melting paint of 156°-157°C. Yield 74.2% of theory
  The methyl ester may be precipitated as the free acid by dissolving in dioxane, addition of 3.15 N methanolic sodium hydroxide solution, pouring the resulting reaction mixture in water, and acidulating the solution with 6 N HCl. After separation and drying, 553.6 g β-N-(3-amino-2,4,6-triiodobenzoyl)- phenylaminopropionic acid having a melting point of 133°-134.5°C are obtained from 571.0 g methyl ester. Overall yield 73.46% of theory.

• Trademarks

  Osbil (Mallinckrodt).

• Therapeutic Function

  Diagnostic aid

• Sicherheitsprofil

  Moderately toxic by ingestion andintravenous routes. When heated to decomposition itemits very toxic fumes of I^- and NOx.

iobenzamic acid Upstream-Materialien And Downstream Produkte

Iobenzaminsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(2)Suppliers

3115-05-7, iobenzamic acid Verwandte Suche: