Viomycin

Bezeichnung:Viomycin

CAS-Nr32988-50-4

Englisch Name:viomycin

CBNumberCB5910382

SummenformelC25H43N13O10

Molgewicht685.7

MOL-Datei32988-50-4.mol

Synonyma

Viomycin

Viomycin physikalisch-chemischer Eigenschaften

Schmelzpunkt	280 °C
Siedepunkt	695.81°C (rough estimate)
Dichte	1.3613 (rough estimate)
Brechungsindex	1.6700 (estimate)
storage temp.	Store at -20°C
Löslichkeit	Water (Slightly)
Aggregatzustand	Powder
pka	pKa 8.2 (Uncertain);10.3 (Uncertain)
Wasserlöslichkeit	Soluble to 75 mM in water
Stabilität	Hygroscopic

Gefahreninformationscode (GHS)

viomycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Viomycin was found independently in 1951, in the culture broth of Streptomyces puniceus by Pfizer Research Laboratories and in that of S. floridae by Parke Davis Co. It shows strong activity against Mycobacterium species and moderate activity against gram-positive and gram-negative bacteria. Viomycin has been used by intramuscular administration to treat tuberculosis, but because of its ototoxicity and renal toxicity it is being replaced by more active and less toxic drugs, such as enviomycin and other antituberculotic antibiotics.
Originator
Vinactane,Ciba,US ,1953
Verwenden
Viomycin is a basic peptide antibiotic, which is an effective agent against multidrug-resistant tuberculosis.
Indications
Viomycin is a complex polypeptide antibiotic that is active against MDR strains of tuberculosis. Cross-resistance between viomycin and kanamycin is less frequent than between viomycin and capreomycin.
Definition
ChEBI: A cyclic peptide antibiotic produced by the actinomycete Streptomyces puniceus, used in the treatment of tuberculosis.
Manufacturing Process
Viomycin is produced by inoculating a nutrient medium with a viable strain of the organism Actinomyces vinaceus. A method for the production of viomycin is set forth in US Patent 2,663,445 comprising inoculating a medium containing soy peptone, beef extract, dextrose, sodium chloride and a silicone antifoaming agent with a spore suspension of Actinomyces vinaceus and incubating the inoculated medium for 120 hours at a temperature of 26°C while passing sterile air through the medium at a rate of 500 ml per liter of medium per minute.
Trademarks
Viocin Sulfate (Pfizer).
Therapeutic Function
Antitubercular
Biologische Aktivität
Member of the tuberactinomycin family of antibiotics . Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans -cleavage of the Neurospora VS ribozyme.

Viomycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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