(Z)-2-[(3,4-Dihydroxyphenyl)methylen]-6-hydroxy-2H-benzofuran-3-one

Bezeichnung:(Z)-2-[(3,4-Dihydroxyphenyl)methylen]-6-hydroxy-2H-benzofuran-3-one

CAS-Nr120-05-8

Englisch Name:SULFURETIN

CBNumberCB5774890

SummenformelC15H10O5

Molgewicht270.24

MOL-Datei120-05-8.mol

Synonyma

(Z)-2-[(3,4-Dihydroxyphenyl)methylen]-6-hydroxy-2H-benzofuran-3-one

(Z)-2-[(3,4-Dihydroxyphenyl)methylen]-6-hydroxy-2H-benzofuran-3-one physikalisch-chemischer Eigenschaften

Schmelzpunkt	295°C
storage temp.	2-8°C
Löslichkeit	Acetone: Soluble Chloroform: Soluble Dichloromethane: Soluble DMSO: SolubleEthyl Acetate: Soluble
Aggregatzustand	Solid
Farbe	Yellow to orange
InChI	1S/C15H10O5/c16-9-2-3-10-13(7-9)20-14(15(10)19)6-8-1-4-11(17)12(18)5-8/h1-7,16-18H/b14-6-
InChIKey	RGNXWPVNPFAADO-NSIKDUERSA-N
SMILES	OC1=CC=C2C(O/C(C2=O)=C\C3=CC(O)=C(O)C=C3)=C1
LogP	1.980 (est)

Sicherheit

WGK Germany	WGK 3
Speicherklasse	11 - Combustible Solids

SULFURETIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis[1]. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM[2].
Definition
ChEBI: Sulfuretin is a member of 1-benzofurans.
Biologische Aktivität
Anti-adipogenic, antineoplastic activity, antioxidative stress, Anti-Inflammatory

in vivo

Sulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation^[1].

Animal Model:	Pathogen-free male BALB/c mice (7-8 weeks old)^[1]
Dosage:	40 μg/kg
Administration:	A single intraperitoneal injection was administered 2 h after the last OVA challenge
Result:	Suppressed OVA-induced chemotaxis and airway inflammation.

Einzelnachweise
[1] Mi-Young Song, et al. Sulfuretin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2010 Sep 10;400(1):83-8. DOI:10.1016/j.bbrc.2010.08.014
[2] Chen, H., et al. Isolation of sulfuretin and butin from Rhus verniciflua Stokes using medium-pressure liquid chromatography and their tyrosinase inhibitory effects. BioRes. 11(1), 759-771.
[3] SO YOUNG KANG Myung J O Ji Young Kang. Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses In Vitro.[J]. Journal of Microbiology, 2012, 50 2: 293-300. DOI: 10.1007/s12275-012-2068-7

(Z)-2-[(3,4-Dihydroxyphenyl)methylen]-6-hydroxy-2H-benzofuran-3-one Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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