4'-Bromvalerophenon

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

4'-Bromovalerophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

• S-Sätze Betriebsanweisung:

  S24/25:Berührung mit den Augen und der Haut vermeiden.

• Chemische Eigenschaften

  yellow crystalline powder

• Verwenden

  4′-Bromovalerophenone may be used in chemical synthesis studies.

• Verwenden

  4'-Bromovalerophenone is a derivative of Valerophenone, which is an aromatic ketone that is often used as a tool in the study of various photochemical processes. Valerophenone is also an inhibitor of the enzyme carbonyl reductase.

• Synthese

  

  693-03-8

  

  18469-37-9

  

  7295-44-5

  GENERAL PROCEDURE: Trifluoromethanesulfonic anhydride (Tf2O, 1.2 eq.) was slowly added dropwise to a solution of 4-bromo-N,N-dimethylbenzamide (1.0 eq.) and 2,6-di-tert-butyl-4-methylpyridine (DTBMP, 1.2 eq.) in dichloromethane (CH2Cl2, 5 mL) cooled to -78 °C. The reaction mixture was gradually warmed up to 0 °C over 2 hours. Subsequently, a solution of butylmagnesium bromide (1.0 eq.) in ether (Et2O) was slowly added dropwise to the reaction mixture at -78 °C and stirring was continued at the same temperature for 2 hours. After completion of the reaction, the reaction was quenched with 15% aqueous hydrochloric acid (5 mL). The organic layer was separated and the aqueous phase was extracted with ether (3 x 5 mL). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The residue was purified by silica gel fast column chromatography to obtain the target product 4-bromovalerophenone. For the separation of the by-product N,N-dimethyl-4-bromobenzamide, the aqueous phase was alkalized with 15% aqueous sodium hydroxide (6 mL) and extracted with dichloromethane (3 x 10 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The residue was purified by silica gel fast column chromatography to give N,N-dimethyl-4-bromobenzamide.

• Einzelnachweise

  [1] Tetrahedron, 2015, vol. 71, # 24, p. 4248 - 4254

4'-Bromovalerophenone Upstream-Materialien And Downstream Produkte

4'-Bromvalerophenon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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7295-44-5, 4'-Bromovalerophenone Verwandte Suche: