3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE Struktur

3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE

Bezeichnung:3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE

CAS-Nr27314-97-2

Englisch Name:3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE

CBNumberCB5442522

SummenformelC7H6N4O2

Molgewicht178.15

MOL-Datei27314-97-2.mol

3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	220°C dec.
Siedepunkt	493.6±28.0 °C(Predicted)
Dichte	1.68±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO: soluble10mg/mL, clear
Aggregatzustand	powder
pka	1.51±0.30(Predicted)
Farbe	orange to dark orange-red

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	DM0671500
HS Code	2933.99.7500

Gefahreninformationscode (GHS)

3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Tirapazamine is a hypoxia-activated anticancer agent. It is converted to an oxidizing radical under hypoxic conditions and can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity. Tirapazamine induces hypoxia-enhanced cytotoxicity in DT40 cells (IC₅₀s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively). It also induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions. In vivo, tirapazamine sensitizes tumors to cisplatin in a mouse RIF-1 fibrosarcoma tumor model. Tirapazamine (0.08 mmol/kg) also sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model.
Chemische Eigenschaften
Orange Needles
Verwenden
Tirapazamine has been used to evaluate its cytotoxic effect on U-251 MG (glioblastoma cell line) cell viability.
Verwenden
A bioreductive anticancer agent. Selectively toxic to cells under hypoxic conditions. An antineoplastic
Definition
ChEBI: A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.
Biochem/physiol Actions
Under hypoxic conditions, tirapazamine is a potent cytotoxic agent that induces apoptosis by inducing breaks in single and double stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin.

3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE Upstream-Materialien And Downstream Produkte

3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

27314-97-2, 3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE Verwandte Suche:

Send Inquriy