10-(2-(Dimethylamino)ethyl)-5,10-dihydro-5-methyl-11H-dibenzo(b,e)-(1,4)diazepin-11-on-mono-hydrochlorid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H301：Giftig bei Verschlucken.

  H332：Gesundheitsschädlich bei Einatmen.

  H412：Schädlich für Wasserorganismen, mit langfristiger Wirkung.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P273：Freisetzung in die Umwelt vermeiden.

  P301+P310：BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P312：Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P321：Besondere Behandlung

  P330：Mund ausspülen.

  P405：Unter Verschluss aufbewahren.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

DIBENZEPINE HCL Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Noveril ,Wander,Switz.,1965

• Verwenden

  Antidepressant.

• Definition

  ChEBI: Dibenzepin hydrochloride is a dibenzodiazepine.

• Manufacturing Process

  4.48 grams of 5-methyl-11-hydroxy-5H-dibenzo[b,e][1,4]diazepine and 0.86
  gram of sodium amide were boiled for one hour in 50 ml of absolute dioxane. After adding a concentrated benzenic solution of β-dimethylamino-ethyl chloride freshly prepared from 3.75 grams of the hydrochloride with concentrated sodium hydroxide solution, taking up in benzene and drying the solution with potash, the mixture was boiled for 16 hours under reflux, whereupon the reaction mixture was concentrated to dryness and the residue distributed between ether and water. By exhaustive extraction of the basic fractions with dilute acetic acid, precipitation with ammonia, taking up the base in ether and working up the ethereal solution, there was obtained 5.05 grams (85% of the theoretical) of 5-methyl-10-β-dimethylamino-ethyl-10,11- dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepine in the form of a viscous yellowish resin with the boiling point 185°C/0.01mm Hg. The base was crystallized from acetone-petroleum ether, MP 116°-117°C. Melting point of the monohydrochloride (from ethanol-ether) 234°-240°C.

• Trademarks

  Deprex;Ecatrol;Hf 1927;Neodit;Victoril.

• Therapeutic Function

  Psychostimulant

• Weltgesundheitsorganisation (WHO)

  Dibenzepin hydrochloride, a tricyclic antidepressant, was introduced in 1968 for the treatment of depressive illness. By 1973 its use in Sweden had been associated with an unexpectedly high number of suicide attempts which led to its withdrawal in that country. Although its use has lapsed in several countries, it remains available in at least eight European countries.

DIBENZEPINE HCL Upstream-Materialien And Downstream Produkte

10-(2-(Dimethylamino)ethyl)-5,10-dihydro-5-methyl-11H-dibenzo(b,e)-(1,4)diazepin-11-on-mono-hydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(10)Suppliers

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