ENALAPRILAT DIHYDRATE

Bezeichnung:ENALAPRILAT DIHYDRATE

CAS-Nr84680-54-6

Englisch Name:ENALAPRILAT DIHYDRATE

CBNumberCB5373019

SummenformelC18H26N2O6

Molgewicht366.41

MOL-Datei84680-54-6.mol

ENALAPRILAT DIHYDRATE physikalisch-chemischer Eigenschaften

Schmelzpunkt	151-159°C
alpha	[α]D25 -53.0～-56.0゜ (c=1, CH3OH) (Calculated on dehydrous basis)
storage temp.	2-8°C
Löslichkeit	H2O: soluble14mg/mL at 60°C (warming for 5 minutes)
Aggregatzustand	Solid
Farbe	White to Off-White
CAS Datenbank	84680-54-6(CAS DataBase Reference)
EPA chemische Informationen	L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-, hydrate (1:2) (84680-54-6)

Sicherheit

WGK Germany	3
RTECS-Nr.	TW3590600
HS Code	2933995300

Gefahreninformationscode (GHS)

ENALAPRILAT DIHYDRATE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril , an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC₅₀ value of 5.8 nM in vitro.
Chemische Eigenschaften
White Solid
Verwenden
Active metabolite of Enalapril. A nonsulfhydryl dipeptide angiotensin converting enzyme (ACE) inhibitor. Enalapril EP Impurity C (Dihydrate).
Verwenden
anthelmintic
Definition
ChEBI: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients wi h nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.
Biochem/physiol Actions
Enalapril, the ethyl ester of?enalaprilat exhibits slight pharmacological activity until it is hydrolyzed in the liver to?enalaprilat. Enalaprilat, a IV form of an angiotensin-converting-enzyme inhibitor (ACE) prevents the transformation of angiotensin I to angiotensin II, a potent vasoconstrictor.

ENALAPRILAT DIHYDRATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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