AEG 3482

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

AEG 3482 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  AEG 3482 is an antiapoptotic compound that inhibits Jun Kinase Activity (JNK) and cell death through induced expression of heat shock protein 70. AEG 3482 shows possible use in the treatment of neurological disorders.

• Definition

  ChEBI: 6-phenyl-2-imidazo[2,1-b][1,3,4]thiadiazolesulfonamide is a member of imidazoles.

• Biologische Aktivität

  Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC 50 = 20 μ M).

• Einzelnachweise

  [1]salehi ah, morris sj, ho wc, etal. , aeg3482 is an antiapoptotic compound that inhibits jun kinase activity and cell death through induced expression of heat shock protein 70. chem biol. 2006 feb;13(2):213-23.
  [2] gallo ka. targeting hsp90 to halt neurodegeneration. chem biol. 2006 feb;13(2):115-6.

AEG 3482 Upstream-Materialien And Downstream Produkte

AEG 3482 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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