Bepheniumhydroxynaphthoat

BEPHENIUM HYDROXYNAPHTHOATE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  antibacterial, antilepretic, antituberculosis

• Verwenden

  Bephenium Hydroxynapthoate is an anthelmintic agent used to treat hookworm infections and ascariasis.

• Indications

  This drug exhibits antihelmintic action by acting as a cholinergic agonist, causing paralysis of the parasite musculature. This facilitates its removal from the intestines. It is used for treating ascariasis, ankylostomiasis, enterobiasis, trichostrongyliasis, and tricocefalosis. A single dose of bephenium heals from 80 to 100% of patients infected with A. duodenale. It is less effective with respect to N. americanus. Synonyms of this drug are aclopar and others.

• Clinical Use

  Bephenium can be used against Ascaris, Ancylostoma, and Trichostrongylus infections; it is less effective against Necator. Occasional adverse reactions occur: nausea, diarrhea, vomiting, headache, vertigo.

• Synthese

  Bephenium, 3-hydroxy-2-naphthoat benzyldimethyl(2-phenoxyethyl) ammonia (38.1.37), is made by reacting the sodium salt of 3-hydroxy-2-naphthoic acid with benzyldimethyl(2-phenoxyethyl)ammonia chloride (38.1.36). This is in turn made from benzyl chloride and N-(2-phenoxyethyl)dimethylamine (38.1.35), which is synthesized by reacting sodium phenolate with 2-dimethylaminoethylchloride.

  

Bepheniumhydroxynaphthoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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