PHOSPHORAMIDON

Bezeichnung:PHOSPHORAMIDON

CAS-Nr119942-99-3

Englisch Name:PHOSPHORAMIDON

CBNumberCB5184723

SummenformelC23H35N3NaO10P

Molgewicht567.51

MOL-Datei119942-99-3.mol

PHOSPHORAMIDON physikalisch-chemischer Eigenschaften

storage temp.	-20°C
Löslichkeit	H₂O: 1 mM Stock solution stable for 1 month at –20° C.
Aggregatzustand	Solid
Farbe	White to pale yellow
BRN	8105669
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 2 months.

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
F	10-21
HS Code	2940000080

Gefahreninformationscode (GHS)

PHOSPHORAMIDON Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Phosphoramidon (119942-99-3) inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC 3.4.24.11), Ki=2 nM.1?Also inhibits neprilysin 2 (Ki~2 nM).2?Also inhibits endothelin-converting enzyme (IC50?= 0.68 μM).3?Induces a dramatic increase in amyloid-beta levels in rodents.4
Verwenden
An endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.
Verwenden
Phosphoramidon is an inhibitor of NEP 24.11 and NEP2. It is an inhibitor of the enzyme thermolysin, a membrane metallo-endopeptidase inhibitor, and an endothelin converting enzyme inhibitor.
Allgemeine Beschreibung
Phosphoramidon [N-(α-rhamnopyranosyl-oxyhydroxyphosphinyl)-Leu-Trp] is a competitive inhibitor of several soluble zinc metalloproteases. Phosphoramidate is produced naturally by Streptomyces?tanashiensis.
Biochem/physiol Actions
Phosphoramidon can inhibit ZMPSTE24, an integral membrane protein zinc metalloprotease. It is capable of blocking thermolysin.
Einzelnachweise
1) Stephenson and Kenny et al. (1987),?The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11.; Biochem. J.,?243?183. 2) Rose?et al.?(2002),?Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin; Biochem. J.,?363?697 3) Ahn?et al.?(1998),?Soluble human endothelin-converting enzyme-1: expression, purification, and demonstration of pronounced pH sensitivity; Arch. Biochem. Biphys.,?359?258 4) Marr and Hafez (2014),?Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance; Front. Aging Neurosci.,?6?187

PHOSPHORAMIDON Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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